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Volume 28, Number 2—February 2022
Research

Role of Anopheles Mosquitoes in Cache Valley Virus Lineage Displacement, New York, USA

Constentin Dieme1Comments to Author , Kiet A. Ngo1, Shaun Tyler, Joseph G. Maffei, Steven D. Zink, Alan P. Dupuis, Cheri A. Koetzner, Chelsea Shultis, Jessica Stout, Anne F. Payne, P. Bryon Backenson, Lili Kuo, Michael A. Drebot, Alexander T. Ciota, and Laura D. Kramer
Author affiliations: New York State Department of Health, Slingerlands, New York, USA (C. Dieme, K.A. Ngo, J.G. Maffei, S.D. Zink, A.P. Dupuis, C.A. Koetzner, C. Shultis, J. Stout, A.F. Payne, L. Kuo, A.T. Ciota, L.D. Kramer); Public Health Agency of Canada, Winnipeg, Manitoba, Canada (S. Tyler, M.A Drebot); New York State Department of Health, Albany, New York, USA (P.B. Backenson); State University of New York at Albany, Albany (A.T. Ciota, L.D. Kramer)

Main Article

Table 5

Relationship between dose and competence of Anopheles quadrimaculatus mosquitoes for Cache Valley virus, New York, USA, 2000‒2016*

Strain Day postinfection Blood meal titer log10 PFU/mL No. infected/no. tested (%) No. disseminated/no. tested (%) No. transmitted.no. tested (%)
L1-NY10 15 5.1 11 /25 (44) 10/11 (90.91) 0/10 (0)
4.2 3/25 (12)† 2/3 (66.67) 0/2 (0)
3
 0/25 (0)
 NT
 NT
L1-NY25 15 6.8 24/25 (96) 22/24 (91.67) 1/22 (4.55)
5.7 13/25 (52) 12/13 (92.31) 1/12 (8.33)
4.5
 3/25 (12)†
 0/3 (0)‡
 NT
L2–15350152 15 5.1 18/25 (72) 18/18 (100) 0/18 (0)
4.3 16/25 (64) 16/16 (100) 2/16 (12.50)
3
 7/25 (28)
 7/7 (100)
 1/7 (14.29)
L2–15330577 15 5.7 19/25 (76) 19/19 (100) 8/19 (42.11)
5 15/25 (60) 15/15 (100) 7/15 (46.67)
3.7
 7/25 (28)
 7/7 (100)
 2/7 (28.57)
R-15041084 15 5.3 15/25 (60) 15/15 (100) 1/15 (6.67)
4.4 13/25 (52) 13/13 (100) 1/13 (7.69)
3.2
 5/25 (20)
 3/5 (60)
 0/3 (0)
R-PA 15 4.9 10/25 (40) 0/10 (0) NT
3.7 6/25 (24) 0/6 (0) NT
2.9 0/25 (0) NT NT

*L1, lineage 1; L2, lineage 2; NT, not tested; R, reassortant (containing lineage 1 large RNA segment and lineage 2 small and medium RNA segments); NT, not tested. †p<0.05: lineage 1 strain infection rate compared with lineage 2 (15350152) strain when mosquitoes were fed on infectious blood ≈4–4.5 log10 PFU/mL titer. ‡p<0.05: lineage 1 strains dissemination rate compared with lineage 2 strains when mosquitoes were fed on infectious blood ≈4–4.5 log10 PFU/mL titer.

Main Article

1These authors contributed equally to this article.

Page created: October 17, 2021
Page updated: January 22, 2022
Page reviewed: January 22, 2022
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