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Volume 28, Number 6—June 2022
Research

Geographic Origin and Vertical Transmission of Leishmania infantum Parasites in Hunting Hounds, United States

Susanne U. FranssenComments to Author , Mandy J. Sanders, Matt Berriman, Christine A. Petersen1, and James A. Cotton1
Author affiliations: Ludwig-Maximilians-Universität Munich, Munich, Germany (S.U. Franssen); Wellcome Sanger Institute, Hinxton, UK (S.U. Franssen, M.J. Sanders, M. Berriman, J.A. Cotton); University of Iowa College of Public Health, Iowa City, Iowa, USA (C.A. Petersen); Center for Emerging Infectious Diseases, University of Iowa, Iowa City (C.A. Petersen)

Main Article

Table

Summary of groups compared in analysis of geographic origin and vertical transmission of Leishmania infantum in hunting hounds, United States*

Group name Sample size Sample names Location Isolation year Time span of isolations, y Host Disease phenotype Source
US_d
 7
 foxymo_01, foxymo_02, foxymo_03, foxymo_04, foxymo_05, foxymo_06, foxymo_07
 Midwestern United States
 2009–2016
 8
 Dog
 CanL
 This study
BR_d 5
 BR_7VLd, BR_11VLd, BR_15VLd, BR_16VLd, BR_17VLd
 Rio Grande do Norte, Brazil
 2010–2012
 3
 Dog
 VL
 (43)
IS_d
 5
 NT16, TH4, TH5, TH6, LRC-L1275
 Israel
 2005–2012
 8
 Dog
 Unknown
 (38)
BR_RGN_VLh 5
 BR_1VLh90, BR_2VLh90, BR_3VLh90, BR_4VLh90, BR_5VLh90
 Rio Grande do Norte, Brazil
 1991–1993
 3
 Human
 VL
 (43)
BR_RGN_VLhAh 6
 BR_12VLh, BR_14VLh, BR_19VLh, BR_8Ah, BR_9Ah, BR_18Ah
 Rio Grande do Norte, Brazil
 2011–2013
 4
 Human
 VL or asymptomatic
 (43)
BR_MA_VLh 6
 MA01A, MA02A, MA03A, MA04A, MA05A, MA07A
 Maranhão, Brazil
 2005–2006
 2
 Human
 VL
 (39)
BR_MG_VLh 9
 MG11A, MG12A, MG13A, MG14A, MG15A, MG16A, MG17A, MG18A, MG19A
 Minas Gerais, Brazil
 2005
 1
 Human
 VL
 (39)
BR_PI_VLh
 11
 PI01A, PI02A, PI03A, PI04A, PI05A, PI07A, PI08A, PI09A, PI10A, PI11A, PI12A
 Piauí, Brazil
 2005–2006
 2
 Human
 VL
 (39)
CH_mix 7
 D_2, Peking, DOG_STRAIN, RACOON_DOG, SKIN, STRAIN_A, STRAIN_B
 China
 1954–1983
 30
 Human, dog, raccoon dog
 VL, unknown
 (38)
FR_mix 4
 LEM1985, LEM3278, LPN114, RM1
 France
 1987–1996
 10
 Human, dog
 CanL, unknown
 (38)
IP_mix† 7
 NT16, TH4, TH5, TH6, LRC-L1275, LRC-L1296, LRC-L1303
 Israel/ Palestine
 2005–2012
 8
 Human, dog
 Unknown
 (38)
IT_mix 5
 ISS174, ISS2420, ISS2426, ISS2429, ISS2508
 Italy
 1985–2002
 18
 Human, dog, sand fly
 VL, CanL, sand fly
 (38)
SP_mix‡ 5 LinJPCM5, BCN83, BCN87, IMT373cl1, IMT260 Spain/ Portugal 1987–2005 19 Human, dog CL, VL, unknown (38, 40),

*Samples and corresponding groups were chosen from the total of 99 isolates (Appendix 2 Figure 2) to represent geographic regions or countries with at least 5 samples available and a focus on groups with dog isolates only, humans only, and a mixture of hosts for comparison. †Samples in groups IS_d are also part of group IP_mix and are indicated in bold. ‡The group SP_mix contains only isolates from Spain and Portugal that are in the clade of the known including several known MON-1 samples. The isolates Inf055, Inf004 from the non–MON-1 clade are not included.

Main Article

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1These senior authors contributed equally to this article.

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