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Volume 28, Number 7—July 2022

Dispatch

Anncaliia algerae Microsporidiosis Diagnosed by Metagenomic Next-Generation Sequencing, China

Chen Liu1, Qin Chen1, Ping Fu, and Yun-Ying ShiComments to Author 
Author affiliations: West China Hospital of Sichuan University, Chengdu, China (C. Liu, Q. Chen, P. Fu, Y.-Y. Shi); Chengdu 363 Hospital of Southwest Medical University, Chengdu (Q. Chen)

Main Article

Table

Clinical characteristics of 12 previously reported cases of human Anncaliia algerae microsporidia infection*

Case reports
 Age, y/sex
 Immunocompromised/underlying conditions
 Related symptoms
 Positive biopsy sample sites
 Treatment
 Outcome
Watts et al. 2014 (1) 67/M Y/RA Myalgias Vastus lateralis Albendazole Survived
66/M
 Y/RA
 Myalgias
 Vastus lateralis
 NG
 Died
Coyle et al. 2004 (2)
 57/F
 Y/RA
 Myalgias
 Quadriceps femoris
 Albendazole
 Died
Boileau et al. 2016 (3)
 49/M
 Y/CLL
 Myalgias
 Vastus lateralis
 Albendazole and fumagillin
 Survived
Sutrave et al. 2018 (4)
 66/M
 Y/GVHD
 Myalgias
 Vastus lateralis
 Albendazole
 Survived
Visvesvara et al. 1999 (5)
 67/M
 N/N
 Eye discomfort
 Cornea
 Albendazole and fumagillin
 Survived
Ziad et al. 2021 (6)
 55/M
 Y/psoriatic arthritis
 Myalgias
 Vastus lateralis, intercostal muscle, and tongue
 Albendazole
 Died
Visvesvara et al. 2005 (7)
 11/M
 Y/ALL
 Skin lesions
 Skin
 NA
 NA
Cali et al. 2010 (8)
 69/M
 Y/CLL
 Hoarseness
 False vocal cord
 Albendazole
 Died
Field et al. 2012 (9)
 49/F
 Y/lung transplant
 Myalgias
 Deltoid and tongue
 NG
 Died
Chacko et al. 2013 (10)
 56/M
 Y/kidney transplant
 Myalgias
 Deltoid
 Albendazole
 Died
Anderson et al. 2019 (11) 60/M Y/kidney and pancreas transplant Skin lesions Lower extremity, finger, tongue, urine, and
sputum		 Albendazole Died

*ALL, acute lymphoblastic leukemia; CLL, chronic lymphocytic leukemia; GVHD, graft-versus-host disease; NA, data not available; NG, treatment for A. algerae was not given because the patient was undiagnosed before death; RA, rheumatoid arthritis.

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References
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  2. Coyle  CM, Weiss  LM, Rhodes  LV III, Cali  A, Takvorian  PM, Brown  DF, et al. Fatal myositis due to the microsporidian Brachiola algerae, a mosquito pathogen. N Engl J Med. 2004;351:42–7. DOIPubMedGoogle Scholar
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1These first authors contributed equally to this article.

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