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Volume 28, Number 8—August 2022
Research

Dominant Carbapenemase-Encoding Plasmids in Clinical Enterobacterales Isolates and Hypervirulent Klebsiella pneumoniae, Singapore

Melvin Yong, Yahua Chen, Guodong Oo, Kai Chirng Chang, Wilson H.W. Chu, Jeanette Teo, Indumathi Venkatachalam, Natascha May Thevasagayam, Prakki S. Rama Sridatta, Vanessa Koh, Andrés E. Marcoleta, Hanrong Chen, Niranjan Nagarajan, Marimuthu Kalisvar, Oon Tek Ng, and Yunn-Hwen GanComments to Author 
Author affiliations: National University of Singapore, Singapore (M. Yong, Y. Chen, G. Oo, K.C. Chang, W.H.W. Chu, N. Nagarajan, M. Kalisvar, Y.-H. Gan); National University Hospital, Singapore (J. Teo); Singapore General Hospital, Singapore (I. Venkatachalam); National Centre for Infectious Diseases, Singapore (N.M. Thevasagayam, P.S.R. Sridatta, V. Koh, M. Kalisvar, O.T. Ng); Tan Tock Seng Hospital, Singapore (V. Koh, M. Kalisvar, O.T. Ng); Universidad de Chile, Santiago, Chile (A.E. Marcelota); Genome Institute of Singapore, Singapore (H. Chen, N. Nagarajan); Nanyang Technological University, Singapore (O.T. Ng)

Main Article

Table

Regression coefficients for pKPC2 and pNDM1 plasmid conjugation frequencies between donor-recipient pairs in a study of carbapenemase-encoding plasmids in clinical Enterobacterales isolates and hypervirulent Klebsiella pneumoniae, Singapore*

Taxonomic relatedness (model parameter) pKPC2
 pNDM1
Mean Bootstrap 95% CI Mean Bootstrap 95% CI
Same strain (β0) −1.73 −1.824 to −1.610 −2.31 −2.405 to −2.212
Same species (β1) −1.38 −1.599 to −1.147 −1.56 −1.771 to −1.317
Same genus (β2) −1.01 −1.162 to −0.866 −2.09 −2.258 to −1.907
Different genus (β3) 0.04 −0.1165 to 0.1988 −1.94 −2.086 to −1.808

*log base 10 conjugation frequencies and their bootstrap 95% CI as described in for the regression equation and fitting procedure are shown.

Main Article

Page created: June 22, 2022
Page updated: July 20, 2022
Page reviewed: July 20, 2022
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