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Volume 30, Number 2—February 2024
Research

Public Health Impact of Paxlovid as Treatment for COVID-19, United States

Yuan Bai1, Zhanwei Du1, Lin Wang1, Eric H.Y. Lau1, Isaac Chun-Hai Fung, Petter Holme, Benjamin J. Cowling, Alison P. Galvani, Robert M. Krug, and Lauren Ancel MeyersComments to Author 
Author affiliations: The University of Hong Kong, Hong Kong (Y. Bai, Z. Du, E.H.Y. Lau, B.J. Cowling); Hong Kong Science and Technology Park, Hong Kong, China (Y. Bai, Z. Du, E.H.Y. Lau, B.J. Cowling); University of Cambridge, Cambridge, UK (L. Wang); Deakin University, Burwood, Victoria, Australia (E.H.Y. Lau); Georgia Southern University, Statesboro, Georgia, USA (I. C.-H. Fung); Aalto University, Espoo, Finland (P. Holme); Kobe University, Kobe, Japan (P. Holme); Yale School of Public Health, New Haven, Connecticut, USA (A.P. Galvani); University of Texas at Austin, Austin, Texas, USA (R.M. Krug, L.A. Meyers); Santa Fe Institute, Santa Fe, New Mexico, USA (L.A. Meyers)

Main Article

Figure 1

Estimated and observed viral load following treatment with placebo (A) or Paxlovid (B) in large-scale campaign treating COVID-19, United States. The left y-axes, black lines, and blue shading indicate the means and 95% CI of SARS-CoV-2 viral load (RNA log10 copies/mL) as estimated by the fitted within-host model. The right y-axes, black dots, and error bars indicate the means and 95% CI of the decrease in viral load since the initiation of treatment as reported in a clinical trial in which 1,126 patients received a placebo and 1,120 patients received Paxlovid during July 16–December 9, 2021 (11). Day one corresponds to the initiation of treatment. Gray circles denote the assumed initial viral load upon infection (V0) corresponding to 1 infectious virus particle in the upper respiratory tract (18).

Figure 1. Estimated and observed viral load following treatment with placebo (A) or Paxlovid (B) in large-scale campaign treating COVID-19, United States. The left y-axes, black lines, and blue shading indicate the means and 95% CI of SARS-CoV-2 viral load (RNA log10 copies/mL) as estimated by the fitted within-host model. The right y-axes, black dots, and error bars indicate the means and 95% CI of the decrease in viral load since the initiation of treatment as reported in a clinical trial in which 1,126 patients received a placebo and 1,120 patients received Paxlovid during July 16–December 9, 2021 (11). Day one corresponds to the initiation of treatment. Gray circles denote the assumed initial viral load upon infection (V0) corresponding to 1 infectious virus particle in the upper respiratory tract (18).

Main Article

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Main Article

1These authors contributed equally to this article.

Page created: December 21, 2023
Page updated: January 24, 2024
Page reviewed: January 24, 2024
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