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Volume 30, Number 6—June 2024
Synopsis

Deciphering Unexpected Vascular Locations of Scedosporium spp. and Lomentospora prolificans Fungal Infections, France

Carole VignalsComments to Author , Joseph Emmerich, Hugues Begueret, Dea Garcia-Hermoso, Guillaume Martin-Blondel, Adela Angoulvant, Damien Blez, Patrick Bruneval, Sophie Cassaing, Emilie Catherinot, Pierre Cahen, Cécile Moluçon-Chabrot, Carole Chevenet, Laurence Delhaes, Lélia Escaut, Marie Faruch, Frédéric Grenouillet, Fabrice Larosa, Lucie Limousin, Elisabeth Longchampt, François Mellot, Céline Nourrisson, Marie-Elisabeth Bougnoux, Olivier Lortholary, Antoine Roux, Laura Rozenblum, Mathilde Puges, Fanny Lanternier, and Didier Bronnimann
Author affiliations: Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France (C. Vignals, H. Begueret, L. Delhaes, M. Puges, D. Bronnimann); Hôpital Saint-Joseph, Paris, France (J. Emmerich); Institut Pasteur, Paris (D. Garcia-Hermoso, M.-E. Bougnoux, O. Lortholary, F. Lanternier); Centre Hospitalier Universitaire de Toulouse, Toulouse, France (G. Martin-Blondel, S. Cassaing, M. Faruch); Hôpital Bicêtre, Le Kremlin-Bicêtre, France (A. Angoulvant, L. Escaut); Hôpital Européen Georges Pompidou, Paris (D. Blez, P. Bruneval); Hôpital Foch, Suresnes, France (E. Catherinot, P. Cahen, L. Limousin, E. Longchampt, F. Mellot, A. Roux); Centre hospitalier universitaire de Clermont-Ferrand, Clermont-Ferrand, France (C. Moluçon-Chabrot, C. Chevenet, C. Nourrisson); Centre hospitalier universitaire de Besançon, Besançon, France (F. Grenouillet); Centre Hospitalier Universitaire de Dijon, Dijon, France (F. Larosa); Hôpital Necker-enfants malades AP-HP, Paris (M.-E. Bougnoux, O. Lortholary, F. Lanternier); Hôpital Pitié-Salpêtrière AP-HP, Paris (L. Rozenblum)

Main Article

Table 3

Patient treatment and outcomes in study of unexpected vascular locations of Scedosporium spp. and Lomentospora prolificans fungal infections, France*

Variables SOS, n = 7 Literature, n = 13 Total, n = 20
Radical surgery
 2/7 (29)
 6/13 (46)
 8/20 (40)
First-line antifungal treatment after microbiologic identification
Monotherapy 1/7 (14) 3/9 (33) 4/16 (25)
Combination therapy 5/7 (71) 5/9 (56) 10/16 (63)
Multitherapy, >3 antifungal agents 1/7 (14) 1/9 (11) 2/16 (13)
Voriconazole 7/7 (100) 9/9 (100) 16/16 (100)
Terbinafine 2/7 (29) 6/9 (67) 8/16 (50)
Caspofungin
 5/7 (71)
 1/9 (11)
 6/16 (38)
Overall IFD-related deaths 5/7 (71) 7/11 (64) 12/18 (67)
Among patients with fungemia 4/4 (100) 3/3 (100) 7/7 (100)
Among patients with aortitis whether or not associated with arteritis 4/5 (80) 7/9 (78) 11/14 (79)
Among patients with arteritis only 1/2 (50) 0/2 (0) 1/4 (25)
Among patients treated with radical surgery and antifungal 1/2 (50) 1/4 (25) 2/6 (33)
Among patients treated with antifungal only
 4/5 (80)
 3/4 (75)
 7/9 (78)
1-month IFD-related deaths 2/7 (29) 5/11 (46) 7/18 (39)

*Values are no./total no. analyzed (%). Denominators are different in some cases because of missing data. Patients had non–central nervous system vascular infections caused by Scedosporium spp. or Lomentospora prolificans; cases were obtained from the SOS and published literature. IFD, invasive fungal disease; SOS, Scedosporiosis/lomentosporiosis Observational Study.

Main Article

Page created: March 28, 2024
Page updated: May 22, 2024
Page reviewed: May 22, 2024
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