Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 30, Number 6—June 2024
Synopsis

Deciphering Unexpected Vascular Locations of Scedosporium spp. and Lomentospora prolificans Fungal Infections, France

Carole VignalsComments to Author , Joseph Emmerich, Hugues Begueret, Dea Garcia-Hermoso, Guillaume Martin-Blondel, Adela Angoulvant, Damien Blez, Patrick Bruneval, Sophie Cassaing, Emilie Catherinot, Pierre Cahen, Cécile Moluçon-Chabrot, Carole Chevenet, Laurence Delhaes, Lélia Escaut, Marie Faruch, Frédéric Grenouillet, Fabrice Larosa, Lucie Limousin, Elisabeth Longchampt, François Mellot, Céline Nourrisson, Marie-Elisabeth Bougnoux, Olivier Lortholary, Antoine Roux, Laura Rozenblum, Mathilde Puges, Fanny Lanternier, and Didier Bronnimann
Author affiliations: Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France (C. Vignals, H. Begueret, L. Delhaes, M. Puges, D. Bronnimann); Hôpital Saint-Joseph, Paris, France (J. Emmerich); Institut Pasteur, Paris (D. Garcia-Hermoso, M.-E. Bougnoux, O. Lortholary, F. Lanternier); Centre Hospitalier Universitaire de Toulouse, Toulouse, France (G. Martin-Blondel, S. Cassaing, M. Faruch); Hôpital Bicêtre, Le Kremlin-Bicêtre, France (A. Angoulvant, L. Escaut); Hôpital Européen Georges Pompidou, Paris (D. Blez, P. Bruneval); Hôpital Foch, Suresnes, France (E. Catherinot, P. Cahen, L. Limousin, E. Longchampt, F. Mellot, A. Roux); Centre hospitalier universitaire de Clermont-Ferrand, Clermont-Ferrand, France (C. Moluçon-Chabrot, C. Chevenet, C. Nourrisson); Centre hospitalier universitaire de Besançon, Besançon, France (F. Grenouillet); Centre Hospitalier Universitaire de Dijon, Dijon, France (F. Larosa); Hôpital Necker-enfants malades AP-HP, Paris (M.-E. Bougnoux, O. Lortholary, F. Lanternier); Hôpital Pitié-Salpêtrière AP-HP, Paris (L. Rozenblum)

Main Article

Figure 1

Abdominal computed tomography scan for case-patient 1 showing arteritis in study of unexpected vascular locations of Scedosporium spp. and Lomentospora prolificans fungal infections, France. Arrow indicates primitive left iliac artery thrombosis and perivascular soft tissue contrast. Data are from the Scedosporiosis/lomentosporiosis Observational Study (12).

Figure 1. Abdominal computed tomography scan for case-patient 1 showing arteritis in study of unexpected vascular locations of Scedosporium spp. and Lomentospora prolificans fungal infections, France. Arrow indicates primitive left iliac artery thrombosis and perivascular soft tissue contrast. Data are from the Scedosporiosis/lomentosporiosis Observational Study (12).

Main Article

References
  1. Ramirez-Garcia  A, Pellon  A, Rementeria  A, Buldain  I, Barreto-Bergter  E, Rollin-Pinheiro  R, et al. Scedosporium and Lomentospora: an updated overview of underrated opportunists. Med Mycol. 2018;56(suppl_1):102–25. DOIPubMedGoogle Scholar
  2. Miceli  MH, Lee  SA. Emerging moulds: epidemiological trends and antifungal resistance. Mycoses. 2011;54:e666–78. DOIPubMedGoogle Scholar
  3. Lackner  M, de Hoog  GS, Yang  L, Ferreira Moreno  L, Ahmed  SA, Andreas  F, et al. Proposed nomenclature for Pseudallescheria, Scedosporium and related genera. Fungal Divers. 2014;67:1–10. DOIGoogle Scholar
  4. Blez  D, Bronnimann  D, Rammaert  B, Zeller  V, Delhaes  L, Hustache  L, et al. Invasive bone and joint infections from the French Scedosporiosis/lomentosporiosis Observational Study (SOS) cohort: no mortality with long-term antifungal treatment and surgery. Med Mycol. 2023;61:myad023.
  5. Seidel  D, Meißner  A, Lackner  M, Piepenbrock  E, Salmanton-García  J, Stecher  M, et al. Prognostic factors in 264 adults with invasive Scedosporium spp. and Lomentospora prolificans infection reported in the literature and FungiScope®. Crit Rev Microbiol. 2019;45:1–21. DOIPubMedGoogle Scholar
  6. Jenks  JD, Seidel  D, Cornely  OA, Chen  S, van Hal  S, Kauffman  C, et al. Clinical characteristics and outcomes of invasive Lomentospora prolificans infections: Analysis of patients in the FungiScope® registry. Mycoses. 2020;63:437–42. DOIPubMedGoogle Scholar
  7. Álvarez-Uría  A, Guinea  JV, Escribano  P, Gómez-Castellá  J, Valerio  M, Galar  A, et al. Invasive Scedosporium and Lomentosora infections in the era of antifungal prophylaxis: A 20-year experience from a single centre in Spain. Mycoses. 2020;63:1195–202. DOIPubMedGoogle Scholar
  8. Lamaris  GA, Chamilos  G, Lewis  RE, Safdar  A, Raad  II, Kontoyiannis  DP. Scedosporium infection in a tertiary care cancer center: a review of 25 cases from 1989-2006. Clin Infect Dis. 2006;43:1580–4. DOIPubMedGoogle Scholar
  9. Troke  P, Aguirrebengoa  K, Arteaga  C, Ellis  D, Heath  CH, Lutsar  I, et al.; Global Scedosporium Study Group. Treatment of scedosporiosis with voriconazole: clinical experience with 107 patients. Antimicrob Agents Chemother. 2008;52:1743–50. DOIPubMedGoogle Scholar
  10. Idigoras  P, Pérez-Trallero  E, Piñeiro  L, Larruskain  J, López-Lopategui  MC, Rodríguez  N, et al. Disseminated infection and colonization by Scedosporium prolificans: a review of 18 cases, 1990-1999. Clin Infect Dis. 2001;32:E158–65. DOIPubMedGoogle Scholar
  11. Heath  CH, Slavin  MA, Sorrell  TC, Handke  R, Harun  A, Phillips  M, et al.; Australian Scedosporium Study Group. Population-based surveillance for scedosporiosis in Australia: epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection. Clin Microbiol Infect. 2009;15:689–93. DOIPubMedGoogle Scholar
  12. Bronnimann  D, Garcia-Hermoso  D, Dromer  F, Lanternier  F, Maulin  L, Leprince  Y, et al.; French Mycoses Study Group; Characterization of the isolates at the NRCMA. Scedosporiosis/lomentosporiosis observational study (SOS): Clinical significance of Scedosporium species identification. Med Mycol. 2021;59:486–97. DOIPubMedGoogle Scholar
  13. Berenguer  J, Rodríguez-Tudela  JL, Richard  C, Alvarez  M, Sanz  MA, Gaztelurrutia  L, et al.; Scedosporium Prolificans Spanish Study Group. Deep infections caused by Scedosporium prolificans. A report on 16 cases in Spain and a review of the literature. Medicine (Baltimore). 1997;76:256–65. DOIPubMedGoogle Scholar
  14. Tintelnot  K, Just-Nübling  G, Horré  R, Graf  B, Sobottka  I, Seibold  M, et al. A review of German Scedosporium prolificans cases from 1993 to 2007. Med Mycol. 2009;47:351–8. DOIPubMedGoogle Scholar
  15. Seidel  D, Hassler  A, Salmanton-García  J, Koehler  P, Mellinghoff  SC, Carlesse  F, et al. Invasive Scedosporium spp. and Lomentospora prolificans infections in pediatric patients: Analysis of 55 cases from FungiScope® and the literature. Int J Infect Dis. 2020;92:114–22. DOIPubMedGoogle Scholar
  16. Johnson  LS, Shields  RK, Clancy  CJ. Epidemiology, clinical manifestations, and outcomes of Scedosporium infections among solid organ transplant recipients. Transpl Infect Dis. 2014;16:578–87. DOIPubMedGoogle Scholar
  17. Rodriguez-Tudela  JL, Berenguer  J, Guarro  J, Kantarcioglu  AS, Horre  R, de Hoog  GS, et al. Epidemiology and outcome of Scedosporium prolificans infection, a review of 162 cases. Med Mycol. 2009;47:359–70. DOIPubMedGoogle Scholar
  18. Carrer  M, Vignals  C, Berard  X, Caradu  C, Battut  AS, Stenson  K, et al. Retrospective multicentric study comparing infectious and noninfectious aortitis. Clin Infect Dis. 2023;76:e1369–78. DOIPubMedGoogle Scholar
  19. Donnelly  JP, Chen  SC, Kauffman  CA, Steinbach  WJ, Baddley  JW, Verweij  PE, et al. Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. Clin Infect Dis. 2020;71:1367–76. DOIPubMedGoogle Scholar
  20. Ong  A, Blyth  CC, Bency  R, Vicaretti  M, Harun  A, Meyer  W, et al. Fatal mycotic aneurysms due to Scedosporium and Pseudallescheria infection. J Clin Microbiol. 2011;49:2067–71. DOIPubMedGoogle Scholar
  21. Howden  BP, Slavin  MA, Schwarer  AP, Mijch  AM. Successful control of disseminated Scedosporium prolificans infection with a combination of voriconazole and terbinafine. Eur J Clin Microbiol Infect Dis. 2003;22:111–3. DOIPubMedGoogle Scholar
  22. Ortmann  C, Wüllenweber  J, Brinkmann  B, Fracasso  T. Fatal mycotic aneurysm caused by Pseudallescheria boydii after near drowning. Int J Legal Med. 2010;124:243–7. DOIPubMedGoogle Scholar
  23. Malinowski  MJ, Halandras  P. Arterial reconstruction for atypical mycotic aneurysms. Vasc Endovascular Surg. 2013;47:45–7. DOIPubMedGoogle Scholar
  24. Centellas Pérez  FJ, Martínez Antolinos  C, Piqueras Sánchez  S, Lorenzo González  I, Llamas Fuentes  F, Gómez Roldán  C. [Scedosporium apiospermum infection in a kidney transplant recipient] [in Spanish]. Rev Iberoam Micol. 2019;36:48–50.PubMedGoogle Scholar
  25. Klinken  EM, Stevenson  BR, Kwok  CHR, Hockley  JA, Lucas  M. Diffuse inflammatory aneurysmal aortitis secondary to Scedosporium apiospermum complex in an immunocompetent individual. Pathology. 2019;51:316–8. DOIPubMedGoogle Scholar
  26. Blasco-Lucas  A, Reyes-Juárez  JL, Nazarena Pizzi  M, Permanyer  E, Evangelista  A, Galiñanes  M. Aortic arch mycotic aneurysm due to Scedosporium apiospermum reconstructed with homografts. Ann Thorac Surg. 2015;99:2218–20. DOIPubMedGoogle Scholar
  27. Thomson  S, Alibhai  K, Winkelaar  G, Lien  D, Halloran  K, Kapasi  A, et al. Case report of vertebral osteomyelitis and mycotic abdominal aortic aneurysm caused by Scedosporium apiospermum in a lung transplant patient with cystic fibrosis. Transplant Proc. 2015;47:204–9. DOIPubMedGoogle Scholar
  28. Sayah  DM, Schwartz  BS, Kukreja  J, Singer  JP, Golden  JA, Leard  LE. Scedosporium prolificans pericarditis and mycotic aortic aneurysm in a lung transplant recipient receiving voriconazole prophylaxis. Transpl Infect Dis. 2013;15:E70–4. DOIPubMedGoogle Scholar
  29. Wakabayashi  Y, Okugawa  S, Tatsuno  K, Ikeda  M, Misawa  Y, Koyano  S, et al. Scedosporium prolificans endocarditis: case report and literature review. Intern Med. 2016;55:79–82. DOIPubMedGoogle Scholar
  30. Valerio  M, Vásquez  V, Álvarez-Uria  A, Zatarain-Nicolás  E, Pavone  P, Martínez-Jiménez  MDC, et al. Disseminated lomentosporiosis in a heart transplant recipient: Case report and review of the literature. Transpl Infect Dis. 2021;23:e13574. DOIPubMedGoogle Scholar
  31. Holmes  NE, Trevillyan  JM, Kidd  SE, Leong  TYM. Locally extensive angio-invasive Scedosporium prolificans infection following resection for squamous cell lung carcinoma. Med Mycol Case Rep. 2013;2:98–102. DOIPubMedGoogle Scholar
  32. Campa-Thompson  MM, West  JA, Guileyardo  JM, Spak  CW, Sloan  LM, Beal  SG. Clinical and morphologic findings in disseminated Scedosporium apiospermum infections in immunocompromised patients. Proc Bayl Univ Med Cent. 2014;27:253–6. DOIPubMedGoogle Scholar
  33. Husain  S, Muñoz  P, Forrest  G, Alexander  BD, Somani  J, Brennan  K, et al. Infections due to Scedosporium apiospermum and Scedosporium prolificans in transplant recipients: clinical characteristics and impact of antifungal agent therapy on outcome. Clin Infect Dis. 2005;40:89–99. DOIPubMedGoogle Scholar
  34. Katragkou  A, Dotis  J, Kotsiou  M, Tamiolaki  M, Roilides  E. Scedosporium apiospermum infection after near-drowning. Mycoses. 2007;50:412–21. DOIPubMedGoogle Scholar
  35. Hurst  RW, Judkins  A, Bolger  W, Chu  A, Loevner  LA. Mycotic aneurysm and cerebral infarction resulting from fungal sinusitis: imaging and pathologic correlation. AJNR Am J Neuroradiol. 2001;22:858–63.PubMedGoogle Scholar
  36. Kasliwal  MK, Reddy  VSK, Sinha  S, Sharma  BS, Das  P, Suri  V. Bilateral anterior cerebral artery aneurysm due to mucormycosis. J Clin Neurosci. 2009;16:156–9. DOIPubMedGoogle Scholar
  37. Sundaram  C, Goel  D, Uppin  SG, Seethajayalakshmi  S, Borgohain  R. Intracranial mycotic aneurysm due to Aspergillus species. J Clin Neurosci. 2007;14:882–6. DOIPubMedGoogle Scholar
  38. Coffey  MJ, Fantone  J III, Stirling  MC, Lynch  JP III. Pseudoaneurysm of pulmonary artery in mucormycosis. Radiographic characteristics and management. Am Rev Respir Dis. 1992;145:1487–90. DOIPubMedGoogle Scholar
  39. Lopez-Pastorini  A, Koryllos  A, Brockmann  M, Windisch  W, Stoelben  E. Pseudoaneurysm of the pulmonary artery with massive haemoptysis due to an invasive pulmonary mucormycosis. Thorax. 2016;71:199–200. DOIPubMedGoogle Scholar
  40. Silva  ME, Malogolowkin  MH, Hall  TR, Sadeghi  AM, Krogstad  P. Mycotic aneurysm of the thoracic aorta due to Aspergillus terreus: case report and review. Clin Infect Dis. 2000;31:1144–8. DOIPubMedGoogle Scholar
  41. Rose  HD, Stuart  JL. Mycotic aneurysm of the thoracic aorta caused by Aspergillus fumigatus. Chest. 1976;70:81–4. DOIPubMedGoogle Scholar
  42. Sanchez-Recalde  A, Maté  I, Merino  JL, Simon  RS, Sobrino  JA. Aspergillus aortitis after cardiac surgery. J Am Coll Cardiol. 2003;41:152–6. DOIPubMedGoogle Scholar

Main Article

Page created: March 28, 2024
Page updated: May 22, 2024
Page reviewed: May 22, 2024
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external