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Volume 30, Number 6—June 2024
Synopsis

Deciphering Unexpected Vascular Locations of Scedosporium spp. and Lomentospora prolificans Fungal Infections, France

Carole VignalsComments to Author , Joseph Emmerich, Hugues Begueret, Dea Garcia-Hermoso, Guillaume Martin-Blondel, Adela Angoulvant, Damien Blez, Patrick Bruneval, Sophie Cassaing, Emilie Catherinot, Pierre Cahen, Cécile Moluçon-Chabrot, Carole Chevenet, Laurence Delhaes, Lélia Escaut, Marie Faruch, Frédéric Grenouillet, Fabrice Larosa, Lucie Limousin, Elisabeth Longchampt, François Mellot, Céline Nourrisson, Marie-Elisabeth Bougnoux, Olivier Lortholary, Antoine Roux, Laura Rozenblum, Mathilde Puges, Fanny Lanternier, and Didier Bronnimann
Author affiliations: Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France (C. Vignals, H. Begueret, L. Delhaes, M. Puges, D. Bronnimann); Hôpital Saint-Joseph, Paris, France (J. Emmerich); Institut Pasteur, Paris (D. Garcia-Hermoso, M.-E. Bougnoux, O. Lortholary, F. Lanternier); Centre Hospitalier Universitaire de Toulouse, Toulouse, France (G. Martin-Blondel, S. Cassaing, M. Faruch); Hôpital Bicêtre, Le Kremlin-Bicêtre, France (A. Angoulvant, L. Escaut); Hôpital Européen Georges Pompidou, Paris (D. Blez, P. Bruneval); Hôpital Foch, Suresnes, France (E. Catherinot, P. Cahen, L. Limousin, E. Longchampt, F. Mellot, A. Roux); Centre hospitalier universitaire de Clermont-Ferrand, Clermont-Ferrand, France (C. Moluçon-Chabrot, C. Chevenet, C. Nourrisson); Centre hospitalier universitaire de Besançon, Besançon, France (F. Grenouillet); Centre Hospitalier Universitaire de Dijon, Dijon, France (F. Larosa); Hôpital Necker-enfants malades AP-HP, Paris (M.-E. Bougnoux, O. Lortholary, F. Lanternier); Hôpital Pitié-Salpêtrière AP-HP, Paris (L. Rozenblum)

Main Article

Table 1

General patient characteristics in study of unexpected vascular locations of Scedosporium spp. and Lomentospora prolificans fungal infections, France*

Variables SOS, n = 7 Literature, n = 13 Total, n = 20
Type of vascular infection
Aortitis 5 (71) 9 (69) 14 (70)
Peripheral arteritis
 6 (86)
 4 (31)
 10 (50)
Age, y (IQR)
 44.0 (37.1–51.5)
 55.0 (44.0–64.0)
 52.5 (42.0–57.4)
Sex
M 4 (57) 6 (46) 10 (50)
F
 3 (43)
 7 (54)
 10 (50)
Main underlying disease/condition
Malignancy 2 (29) 2 (15) 4 (20)
Including hemopathy 2 (29) 1 (8) 3 (15)
Including solid neoplasia 0 1 (8) 1 (5)
Solid organ transplant 3 (43) 7 (54) 10 (50)
Trauma 2 (29) 2 (15) 4 (20)
Near drowning 0 1 (8) 1 (5)
No risk factor
 0
 1 (8)
 1 (5)
Neutropenia 1 (14) 1 (8) 2 (10)
Prior colonization 0 2 (15) 2 (10)
Breakthrough infections
 1 (14)
 2 (15)
 3 (15)
Fungus identification
S. apiospermum 4 (57) 8 (62) 12 (60)
L. prolificans 2 (29) 5 (39) 7 (35)
S. apiospermum and L. prolificans
 1 (14)
 0
 1 (5)
Disseminated infection 7 (100) 8 (62) 15 (75)
Fungemia† 4/17 (57) 4/11 (36) 8/18 (44)

*Values are no. (%) except as indicated. Patients had non–central nervous system vascular infections caused by Scedosporium spp. or Lomentospora prolificans; cases were obtained from the SOS and from published literature. IQR, interquartile range; SOS, Scedosporiosis/lomentosporiosis Observational Study. †Blood culture data were not available from published literature for 2 patients. Denominators indicate the total number of patients evaluated.

Main Article

Page created: March 28, 2024
Page updated: May 22, 2024
Page reviewed: May 22, 2024
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