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Volume 30, Number 7—July 2024
Dispatch

Avian Influenza A(H5N1) Virus among Dairy Cattle, Texas, USA

Judith U. Oguzie1, Lyudmyla V. Marushchak1, Ismaila Shittu, John A. Lednicky, Aaron L. Miller, Haiping Hao, Martha I. Nelson, and Gregory C. GrayComments to Author 
Author affiliations: University of Texas Medical Branch, Galveston, Texas, USA (J.U. Oguzie, L.V. Marushchak, I. Shittu, A.L. Miller, H. Hao, G.C. Gray); University of Florida, Gainesville, Florida, USA (J.A. Lednicky); National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA (M.I. Nelson)

Main Article

Table

Identified mutations, by gene segment, in avian influenza A(H5N1) strain A/cattle/Texas/56283/2024 (H5N1) detected in cattle on a dairy farm, Texas, USA*

Mutation region All mutations Red mutation Orange mutations Reference strain
HA
 K3N, G16S, N110S, L120M, L131Q, T139P, T156A, Q185R, V194I, A201E, T211I, V226A, N252D, E284G, M285V, I298V, K492E, I526V, V538A, I547M, V548M
N110S, L131Q, T139P, V226A
 A/Sichuan/26221/2014 (H5N6)
M1 N82S, N85S, N87T, T140A, F144L, M165I, V166A, A200V, A227T, K230R, M248L A/duck/Guangdong/E1/2012 (H10N8)
M2
 R12K, K18N, V27A, I51V, R61G, D88N
 V27A
A/mallard/Astrakhan/263/1982 (H14N5)
NA
 I8T, V17I, I20V, H44Y, A46P, V67I, N71S, T76A, K78Q, A81T, V99I, H100Y, H155Y, T188I, M258I, L269M, E287D, T289M, V321I, G336S, V338M, S339P, P340S, N366S, G382E, A395E, I418M, S434N, D460G
A/goose/Guangdong/1/1996 (H5N1)
NP
 Y52H, S482N
A/chicken/BCFAV8//2014 (H5N2)
NS1 S7L, R21Q, S87P, C116S, D139N, A223E, V226I A223E, V226I A/duck/Guangdong/E1/2012 (H10N8)
NS2
 E67G
E67G
 A/quail/Italy/1117/1965 (H10N8)
PA
 A36T, I61M, T85A, K113R, L219I, S277P, A404S, M441V, K497R, Y535H, I543L, S558L, T608S
A36T, A404S
 A/Netherlands/219/2003 (H7N7)
PB1 T59S, E75D, I114V, I171V, M179I, S384T, V401A, A587P A/Singapore/1/1957 (H2N2)
PB2 T58A, V109I, V139I, E362G, K389R, D441N, V478I, V495I, M631L, V649I, M676A A/duck/Guangdong/E1/2012 (H10N8)

*As listed in FluSurver (http://flusurver.bii.a-star.edu.sg), red mutations alter viral virulence, cause strong drug resistance, or reverse the effects of the premature STOP codon. These have an assigned warning level of 3 (most significant); Orange mutations are those at drug binding sites or sites that alter host-cell specificity. These have a warning level 2 (significant). In addition, mutations at sites known to result in antigenic shifts or cause mild drug resistance are in this group. HA, hemagglutinin; M, matrix; NA, neuraminidase; NP, nucleoprotein; NS, nonstructural; PA, polymerase acidic; PB, polymerase basic.

Main Article

1These first authors contributed equally to this article.

Page created: June 01, 2024
Page updated: June 22, 2024
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