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Volume 30, Number 8—August 2024
Research

Environmental Hot Spots and Resistance-Associated Application Practices for Azole-Resistant Aspergillus fumigatus, Denmark, 2020–2023

Maiken Cavling ArendrupComments to Author , Rasmus Krøger Hare, Karin Meinike Jørgensen, Ulla E. Bollmann, Tina B. Bech, Cecilie Cetti Hansen, Thies M. Heick, and Lise Nistrup Jørgensen
Author affiliations: Rigshospitalet, Copenhagen University, Copenhagen, Denmark (M.C. Arendrup); Statens Serum Institut, Copenhagen (M.C. Arendrup, R.K. Hare, K.M. Jørgensen); Geological Survey of Denmark and Greenland, Copenhagen (U.E. Bollmann, T.B. Bech, C.C. Hansen); Aarhus University, Flakkebjerg, Slagelse, Denmark (T.M. Heick, L.N. Jørgensen)

Main Article

Figure 1

Minimum spanning tree of 232 Aspergillus fumigatus genotyped study isolates including 741 Denmark background isolates (627 isolates from 326 patients and 114 isolates from the environment) for study of environmental hot spots and resistance-related application practices for azole-resistant A. fumigatus, Denmark, 2020–2022. Colors emphasize isolates with environmental azole resistance mechanisms, TR34/L98H (red) or TR46/Y121F/T289A (purple). With a few exceptions, all TR34/L98H and TR46/Y121F/T289A reside on the left side of the tree. Moreover, several TR34/L98H clusters include patient and environmental isolates, of which cluster 1 displays almost identical genotypes.

Figure 1. Minimum spanning tree of 232 Aspergillus fumigatus genotyped study isolates including 741 Denmark background isolates (627 isolates from 326 patients and 114 isolates from the environment) for study of environmental hot spots and resistance-related application practices for azole-resistant A. fumigatus, Denmark, 2020–2022. Colors emphasize isolates with environmental azole resistance mechanisms, TR34/L98H (red) or TR46/Y121F/T289A (purple). With a few exceptions, all TR34/L98H and TR46/Y121F/T289A reside on the left side of the tree. Moreover, several TR34/L98H clusters include patient and environmental isolates, of which cluster 1 displays almost identical genotypes.

Main Article

Page created: June 14, 2024
Page updated: July 20, 2024
Page reviewed: July 20, 2024
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