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Volume 30, Number 9—September 2024

Research

Autochthonous Leishmaniasis Caused by Leishmania tropica, Identified by Using Whole-Genome Sequencing, Sri Lanka

Hermali Silva1, Tiago R. Ferreira1, Kajan Muneeswaran, Sumudu R. Samarasinghe, Eliza V.C. Alves-Ferreira, Michael E. Grigg, Naduviladath V. Chandrasekharan, David L. Sacks, and Nadira D. KarunaweeraComments to Author 
Author affiliations: University of Colombo, Colombo, Sri Lanka (H. Silva, K. Muneeswaran, S.R. Samarasinghe, N.V. Chandrasekharan, N.D. Karunaweera); Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland, USA (T.R. Ferreira, E.V.C. Alves-Ferreira, M.E. Grigg, D.L. Sacks)

Main Article

Figure 8

Coverage plots of whole-genome sequencing reads mapped to the reference strain L. donovani cutaneous leishmaniasis from Sri Lanka. A) The absence of reads on the A2 gene locus in the classic cutaneous species (L. major and L. tropica) indicates a truncated pseudogene sequence. B) Variable levels of sequence heterogeneity for the A2 gene are observed among the different L. donovani clinical isolates from Sri Lanka. Plaque skin lesion phenotype was associated with A2 gene sequences that are highly similar to the reference. SL, Sri Lanka.

Figure 8. Coverage plots of whole-genome sequencing reads mapped to the reference strain L. donovani cutaneous leishmaniasis from Sri Lanka. A) The absence of reads on the A2 gene locus in the classic cutaneous species (L. major and L. tropica) indicates a truncated pseudogene sequence. B) Variable levels of sequence heterogeneity for the A2 gene are observed among the different L. donovani clinical isolates from Sri Lanka. Plaque skin lesion phenotype was associated with A2 gene sequences that are highly similar to the reference. SL, Sri Lanka.

Main Article

1These authors contributed equally to this article.

Page created: August 07, 2024
Page updated: August 20, 2024
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