Ecologic, Geoclimatic, and Genomic Factors Modulating Plague Epidemics in Primary Natural Focus, Brazil
Matheus F. Bezerra
, Diego L.R.S. Fernandes, Igor V. Rocha, João L.L.P. Pitta, Natan D.A. Freitas, André L.S. Oliveira, Ricardo J.P.S. Guimarães, Elainne C.S. Gomes, Cecília Siliansky de Andreazzi, Marise Sobreira, Antonio M. Rezende, Pedro Cordeiro-Estrela, and Alzira M.P. Almeida
Author affiliations: Instituto Aggeu Magalhães, Fiocruz, Brazil (M.F. Bezerra, D.L.R.S Fernandes, I.V. Rocha, J.L.L.P. Pitta, E.C.S. Gomes, M. Sobreira, A.M. Rezende, A.M.P. Almeida); Laboratório de Mamíferos, Pós Graduação em Ciências Biológicas (Zoologia), Universidade Federal da Paraíba, João Pessoa, Brazil (N.D.A. Freitas, P. Cordeiro-Estrela); Núcleo de Geoprocessamento, Instituto Aggeu Magalhães, Fiocruz (A.L.S. Oliveira); Laboratório de Geoprocessamento, Instituto Evandro Chagas, Belém, Brazil (R.J.P.S. Guimarães); Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil (C.S. de Andreazzi); Universidad Complutense de Madrid, Madrid, Spain (C.S. de Andreazzi); International Platform for Science, Technology and Innovation in Health, PICTIS, Ílhavo, Portugal (C.S. de Andreazzi); Group of Biotechnology Applied to Pathogens, René Rachou Institute, Fiocruz (A.M. Rezende)
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Figure 11
Figure 11. Human risk prediction in a study of ecologic, geoclimatic, and genomic factors modulating plague epidemics in primary natural focus, Brazil. Prediction used ecologic variables at a monthly level. A) Receiver operating characteristic curves and cutoff values of the ecologic variables for the prediction of >2 human cases within the same month. B) Sensitivity, specificity, and AUC for each variable. Error bars indicate 95% CIs. AUC, area under the curve.
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