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Volume 31, Number 1—January 2025
Research

Cefiderocol Resistance Conferred by Plasmid-Located Ferric Citrate Transport System in Klebsiella pneumoniae Carbapenemase–Producing K. pneumoniae

Riccardo Polani, Alice De Francesco, Dario Tomolillo, Irene Artuso, Michele Equestre, Rita Trirocco, Gabriele Arcari, Guido Antonelli, Laura Villa, Gianni Prosseda, Paolo Visca, and Alessandra CarattoliComments to Author 
Author affiliation: Sapienza University of Rome, Rome, Italy (R. Polani, A. De Francesco, D. Tomolillo, R. Trirocco, G. Arcari, G. Antonelli, G. Prosseda, A. Carattoli); University of Pavia, Pavia, ltaly (D. Tomolillo); Istituto Superiore di Sanità, Rome (I. Artuso, M. Equestre, L. Villa); University of Insubria, Varese, Italy (G. Arcari); Sapienza University Hospital “Policlinico Umberto I,” Rome (G. Antonelli); Roma Tre University, Rome (P. Visca)

Main Article

Figure 2

FDC MICs in study of cefiderocol resistance conferred by plasmid-located ferric citrate transport system in Klebsiella pneumoniae carbapenemase–producing K. pneumoniae. FDC susceptibility tests were performed according to manufacturer directives, with concentrations of 0 µM, 0.5 µM, and 5 µM ammonium ferric citrate on Escherichia coli DH5-α cells carrying different combinations of pKpQIL, R69c, and R69c-FEC plasmids. FDC, cefiderocol; KPC, carbapenemase–producing Klebsiella pneumoniae.

Figure 2. FDC MICs in study of cefiderocol resistance conferred by plasmid-located ferric citrate transport system in Klebsiella pneumoniae carbapenemase–producing K. pneumoniae. FDC susceptibility tests were performed according to manufacturer directives, with concentrations of 0 µM, 0.5 µM, and 5 µM ammonium ferric citrate on Escherichia coli DH5-α cells carrying different combinations of pKpQIL, R69c, and R69c-FEC plasmids. FDC, cefiderocol; KPC, carbapenemase–producing Klebsiella pneumoniae.

Main Article

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