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Volume 31, Number 1—January 2025
Research

Cefiderocol Resistance Conferred by Plasmid-Located Ferric Citrate Transport System in Klebsiella pneumoniae Carbapenemase–Producing K. pneumoniae

Riccardo Polani, Alice De Francesco, Dario Tomolillo, Irene Artuso, Michele Equestre, Rita Trirocco, Gabriele Arcari, Guido Antonelli, Laura Villa, Gianni Prosseda, Paolo Visca, and Alessandra CarattoliComments to Author 
Author affiliation: Sapienza University of Rome, Rome, Italy (R. Polani, A. De Francesco, D. Tomolillo, R. Trirocco, G. Arcari, G. Antonelli, G. Prosseda, A. Carattoli); University of Pavia, Pavia, ltaly (D. Tomolillo); Istituto Superiore di Sanità, Rome (I. Artuso, M. Equestre, L. Villa); University of Insubria, Varese, Italy (G. Arcari); Sapienza University Hospital “Policlinico Umberto I,” Rome (G. Antonelli); Roma Tre University, Rome (P. Visca)

Main Article

Figure 7

Phylogenetic analysis based on core-genome alignments of 1,516 Klebsiella pneumoniae ST307 isolates in study of cefiderocol resistance conferred by plasmid-located ferric citrate transport system in K. pneumoniae carbapenemase–producing K. pneumoniae. The trees are midpoint rooted, and the scale bar represents the number of substitutions per site. The presence of the fec operon is indicated in red; blaKPC, blaVIM, and blaNDM genes in black; and the FIB(K) replicon in orange. Yellow shading indicates genomes sequenced in this study or our previous studies (Appendix 1, Table 1). The best-fit model was selected by ModelFinder (34). The trees were visualized with Microreact (https://microreact.org) and adjusted by using the InkScape software (https://www.inkscape.org). ST, sequence type.

Figure 7. Phylogenetic analysis based on core-genome alignments of 1,516 Klebsiella pneumoniae ST307 isolates in study of cefiderocol resistance conferred by plasmid-located ferric citrate transport system in K. pneumoniae carbapenemase–producing K. pneumoniae. The trees are midpoint rooted, and the scale bar represents the number of substitutions per site. The presence of the fec operon is indicated in red; blaKPC, blaVIM, and blaNDM genes in black; and the FIB(K) replicon in orange. Yellow shading indicates genomes sequenced in this study or our previous studies (Appendix 1, Table 1). The best-fit model was selected by ModelFinder (34). The trees were visualized with Microreact (https://microreact.org) and adjusted by using the InkScape software (https://www.inkscape.org). ST, sequence type.

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