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Volume 31, Number 2—February 2025
Research

Prions in Muscles of Cervids with Chronic Wasting Disease, Norway

Tram T. Vuong1Comments to Author , Federico A. Cazzaniga1, Linh Tran, Jørn Våge, Michele Di Bari, Laura Pirisinu, Claudia D’Agostino, Romolo Nonno, Fabio Moda2, and Sylvie L. Benestad2
Author affiliation: Norwegian Veterinary Institute, Ås, Norway (T.T. Vuong, L. Tran, J. Våge, S.L. Benestad); Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy (F.A. Cazzaniga, F. Moda); Istituto Superiore di Sanità, Rome, Italy (M.D. Bari, L. Pirisinu, C. D’Agostino, R. Nonno); Università degli Studi di Milano (F. Moda)

Main Article

Table 2

Summary of PMCA amplification of prions in selected peripheral tissues from CWD-affected reindeer, moose, and a red deer with different strains in a study of prions in muscles of cervids with CWD, Norway*

Tissues or organs
 Reindeer
Moose
 Red deer
A
 B
 A
 B
 C
 D
Lymph nodes
Retropharyngeal
 NA
 NA
NA
 Amp
 NA
 NA
 Amp
Parotid
 Amp
 Amp
Amp, inf
 NA
 Amp
 NA
 NA
Mandibular
 NA
 NA
NA
 NA
 NA
 No Amp
 NA
Prescapular
 Amp
 Amp
NA
 NA
 No amp, no inf
 Inc
 No amp, no inf
Axillary
 NA
 NA
Amp
 NA
 NA
 NA
 NA
Popliteal
 Amp
 Amp
No amp, no inf
 NA
 No amp
 No amp
 NA
Peripheral nerves
Brachial plexus
 Amp
 NA
Amp
 NA
 Amp
 NA
 Amp
Ischiadic nerve
 Amp
 Amp
Amp
 NA
 Amp
 Amp
 Amp
Optic nerve
 Amp
 NA
Amp
 NA
 Amp
 NA
 Amp
Muscles
Masseter
 Amp
 Amp
Amp
 Amp
 Amp
 Amp
 Amp
Triceps brachii
 Inc
 No amp
Amp
 Amp
 Amp
 Inc
 Amp
Psoas
 Amp
 Amp
Amp
 Amp
 Amp
 No amp
 No amp
Longissimus dorsi
 Amp
 NA
Amp, no inf
 Amp
 Amp, no Inf
 No amp
 Inc
Semitendinosus
 No amp
 NA
No amp
 Amp
 Amp
 No amp
 No amp
Ocular
 Amp
 NA
Amp, inf
 NA
 Amp
 NA
 Amp
Lingual
 Amp
 Amp
Amp
 NA
 Amp
 NA
 Amp
Cardiac Amp Amp NA Amp No amp No amp NA

*Amp, positive amplification; CWD, chronic wasting disease; inc, inconclusive results due to inconsistencies in the 2 laboratories; inf, positive infectivity in Bv109I voles; NA, not available/not tested; no amp, no amplification; no inf, no infectivity in Bv109I voles; PMCA, protein misfolding cyclic amplification.

Main Article

1These first authors contributed equally to this article.

2These authors are co–senior authors.

Page created: December 30, 2024
Page updated: January 31, 2025
Page reviewed: January 31, 2025
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