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Volume 31, Number 3—March 2025
Dispatch

Simultaneous Detection of Sarcocystis hominis, S. heydorni, and S. sigmoideus in Human Intestinal Sarcocystosis, France, 2021–2024

Maxime Moniot, Patricia Combes, Damien Costa, Nicolas Argy, Marie-Fleur Durieux, Thomas Nicol, Céline Nourrisson, and Philippe PoirierComments to Author 
Author affiliation: CHU Clermont-Ferrand Service de Parasitologie-Mycologie, Clermont-Ferrand, France (M. Moniot); CHU Clermont-Ferrand Centre National de Référence des cryptosporidioses, microsporidies et autres protozooses digestives, Clermont-Ferrand (M. Moniot, P. Combes, D. Costa, C. Nourrisson, P. Poirier); Université Rouen Normandie, Rouen, France (D. Costa); CHU Rouen Centre National de Référence Cryptosporidioses, Microsporidies et autres protozooses digestives (Centre coordonnateur), Rouen (D. Costa); Hopital Bichat-Claude Bernard, Paris, France (N. Argy); MERIT UMR 216, IRD, Faculté de pharmacie de Paris, Université Paris Cité, Paris (N. Argy); Centre de biologie et de recherche en santé, Hôpital Universitaire Dupuytren, Limoges, France (M. Durieux); CHU Angers, Angers, France (T. Nicol); Microbes, Intestin, Inflammation et Susceptibilité de l’Hôte, UMR Inserm/Université Clermont Auvergne U1071, USC INRAE 1382, Clermont-Ferrand (C. Nourrisson, P. Poirier)

Main Article

Table

Clinical manifestations and molecular findings for 19 cases of human intestinal sarcocystosis, France, 2021–2024*

Case
ID		 Age, y/sex Signs/symptoms Sample date HTS
 Sarcocystis species GenBank accession no. of reference sequence
Contigs No. (%) reads
S01-01 71/F Acute diarrhea 2021 Oct 25 Contig 1 4,405 (83.2) S. sigmoideus OR543013
Contig 2
 730 (13.8)
 S. hominis
 OR543019
S01-02 94/F Chronic diarrhea, alternating constipation 2022 Jan 22 Contig 1 2,470 (46.1) S. sigmoideus OR543013
Contig 2 1,582 (29.5) S. hominis OR543021
Contig 3
 342 (6.4)
 S. hominis
 MK497842
S01-03 33/F Acute diarrhea, abdominal pain, ileitis, Salmonella infection
 2022 Aug 21 Contig 1 5,768 (64.7) S. hominis OR543021
Contig 2
 2,993 (33.6)
 S. hominis
 MK497842
S01-04 48/M Abdominal pain, anal itching
 2023 Feb 23 Contig 1 3,065 (56.1) S. hominis OR543021
Contig 2
 2,399 (43.9)
 S. hominis
 MK497842
S01-05 35/F None† 2023 Mar 16 Contig 1 2,674 (73.4) S. hominis MK497842
Contig 2
 914 (25.1)
 S. heydorni
 KX057995
S01-06 73/M Chronic diarrhea, abdominal pain, weight loss, eosinophilia
 2023 May 9 Contig 1 4,767 (95.2) S. sigmoideus OR543013
Contig 2
 99 (2.0)
 S. hominis
 OR543021
S01-08 24/F Acute diarrhea, nausea 2023 Jun 19 Contig 1 3,213 (68.5) S. hominis OR543019
Contig 2 750 (16.0) S. heydorni KX057995
Contig 3
 673 (8.0)
 S. hominis
 MK497842
S01-09 76/F Chronic diarrhea, abdominal pain 2023 Aug 30 Contig 1 2,787 (50.6) S. hominis OR543019
Contig 2 1,881 (34.2) S. hominis MK497842
Contig 3
 603 (11.0)
 S. sigmoideus
 OR543013
S01-10
 22/F
 Chronic diarrhea, asthenia, multiple food intolerances, fibroscopic gastritis and rectitis
 2023 Nov 14
 Contig 1
 5,049 (100)
 S. hominis
 OR543021
S01-11 19/M Occasional diarrhea, sometimes blood in feces 2023 Nov 18 Contig 1 1,653 (39.5) S. sigmoideus OR543013
Contig 2 1,049 (25.1) S. hominis OR543021
Contig 3
 927 (22.2)
 S. heydorni
 KX057995
S01-12 68/F Chronic diarrhea, abdominal pain 2023 Dec 11 Contig 1 2,410 (48.8) S. hominis OR543021
Contig 2 961 (19.4) S. hominis MK497842
Contig 3
 869 (17.6)
 S. sigmoideus
 OR543013
S01-13
 26/M
 Abdominal pain
 2023 Dec 18
 Contig 1
 5,072 (99.9)
 S. hominis
 OR543021
S01-14
 57/M
 None‡
 2024 Jan 9
 Contig 1
 4,246 (97.4)
 S. hominis
 OR543019
S01-15 79/M Chronic diarrhea, abdominal pain, CDP 10 y prior 2024 Apr 3 Contig 1 1,428 (36.1) S. hominis OR543021
Contig 2 767 (19.4) S. hominis MK497842
Contig 3 696 (17.6) S. heydorni KX057995
Contig 4
 662 (16.7)
 S. sigmoideus
 OR543013
S01-16 62/M Chronic diarrhea, abdominal pain 2024 Jun 12 Contig 1 1,171 (28.6) S. hominis MK497842
Contig 2 1,153 (28.2) S. sigmoideus OR543013
Contig 3 641 (15.7) S. heydorni KX057995
Contig 4
 590 (16.9)
 S. hominis
 OR543021
S01-18
 73/M
 Acute diarrhea, weight loss
 2023 Jan 10
 Contig 1
 4,103 (100)
 S. hominis
 MK497842
S01-19
 52/M
 Chronic diarrhea, abdominal pain, weight loss, ulcerative colitis, Taenia saginata infection
 2023 Sep 29
 Contig 1
 7,302 (100)
 S. hominis
 OR543019
S01-27
 63/M
 Abdominal pain, nausea, eosinophilia
 2024 Jul 10
 Contig 1
 4,696 (99.9)
 S. hominis
 OR543021
S01-28 48/M Chronic diarrhea, rectal cancer diagnosis 2024 Jul 22 Contig 1 3,976 (57.2) S. sigmoideus OR543013
Contig 2 2,578 (37.1) S. hominis OR543021

*CDP, cephalic duodenopancreatectomy; HTS, high-throughput sequencing; ID, identification. †Preemployment medical screening of food industry worker. ‡Systematic screening in kidney transplantation.

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Page created: February 04, 2025
Page updated: February 28, 2025
Page reviewed: February 28, 2025
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