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Volume 31, Number 4—April 2025
Research

Neutralizing Antibodies against California Serogroup Orthobunyaviruses in Human Serum Samples, Montana, USA

Tyson A. Woods1, Stephen F. Johnson1, Alyssa B. Evans2, and Karin E. PetersonComments to Author 
Author affiliation: Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA

Main Article

Figure 3

Serum analysis in a study of neutralizing antibodies against California serogroup orthobunyaviruses in human serum samples, Montana, USA. A) Screening process; B) general relationship between analyzed viruses. All samples were initially screened for neutralizing antibody against JCV using a 5-fold dilution series starting at a 1:10 dilution. Samples that were positive for JCV neutralization were subsequently screened for neutralization of other California serogroup viruses and a non–cross-reacting Bunyamwera serogroup virus, CVV. CEV, California encephalitis virus; CVV, Cache Valley virus; JCV, Jamestown Canyon virus; LACV, La Crosse virus; SSHV, snowshoe hare virus; TVTV, Trivittatus virus.

Figure 3. Serum analysis in a study of neutralizing antibodies against California serogroup orthobunyaviruses in human serum samples, Montana, USA. A) Screening process; B) general relationship between analyzed viruses. All samples were initially screened for neutralizing antibody against JCV using a 5-fold dilution series starting at a 1:10 dilution. Samples that were positive for JCV neutralization were subsequently screened for neutralization of other California serogroup viruses and a non–cross-reacting Bunyamwera serogroup virus, CVV. CEV, California encephalitis virus; CVV, Cache Valley virus; JCV, Jamestown Canyon virus; LACV, La Crosse virus; SSHV, snowshoe hare virus; TVTV, Trivittatus virus.

Main Article

1These first authors contributed equally to this article.

2Current affiliation: Department of Microbiology and Cell Biology, Montana State University, Bozeman, Montana, USA

Page created: February 08, 2025
Page updated: March 24, 2025
Page reviewed: March 24, 2025
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