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Volume 31, Number 4—April 2025
Research
Neutralizing Antibodies against California Serogroup Orthobunyaviruses in Human Serum Samples, Montana, USA
Table 3
Unbiased analysis of the 100 samples from east region in a study of neutralizing antibodies against California serogroup orthobunyaviruses in human serum samples, Montana, USA*
| Viruses | Neutralizing antibody titer dilution |
|||
|---|---|---|---|---|
| >1,250 | 250 | 50 | 10† | |
| Total no. samples |
2 |
21 |
20 |
45 |
| No. single positive‡ | ||||
| JCV | 0 | 2 | 1 | 0 |
| SSHV | 0 | 0 | 0 | 0 |
| LACV | 0 | 9 | 1 | 0 |
| CEV | 1 | 2 | 2 | 2 |
| TVTV | 0 | 2 | 9 | 25 |
| CVV |
0 |
0 |
2 |
2 |
| No. dual positive§ | ||||
| JCV + LACV | 0 | 1 | 0 | 0 |
| JCV + CEV | 1 | 0 | 2 | 1 |
| LACV + TVTV | 0 | 2 | 1 | 0 |
| CEV + TVTV | 0 | 0 | 1 | 8 |
| TVTV + CVV |
0 |
0 |
0 |
4 |
| No. triple positive¶ | 0 | 3 | 1 | 3 |
*Highest titer of neutralization >50 for any California serogroup virus. CEV, California encephalitis virus; CVV, Cache Valley virus; E, East; JCV, James Canyon virus; LACV, La Crosse virus; NC, north central; NW, northwest; SC, south central; SSHV, snowshoe hare virus; SW, southwest; TVTV, Trivittatus virus. †Number detected only at 1:10 dilution. ‡Samples that had a 5× titer for 1 specific virus. §Samples with highest titer against 2 viruses. ¶Samples with highest titer against >2 viruses.
1These first authors contributed equally to this article.
2Current affiliation: Department of Microbiology and Cell Biology, Montana State University, Bozeman, Montana, USA