Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.
Volume 31, Number 4—April 2025
Research
Neutralizing Antibodies against California Serogroup Orthobunyaviruses in Human Serum Samples, Montana, USA
Table 1
Positivity of samples tested in a study of neutralizing antibodies against California serogroup orthobunyaviruses in human serum samples, Montana, USA*
| Characteristics | Total | Total – SW2 | % JCV-positive, n = 159 |
% Dual positive samples, n = 87 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Hospital region |
||||||||||
| NW | SW1 | SW2 | NC | SC | E | |||||
| Total samples |
190 |
103 |
212 |
201 |
100 |
100 |
906 |
694 |
NA |
NA |
| JCV-positive |
55 (29) |
21 (20) |
31 (15) |
35 (17) |
17 (17) |
31 (31) |
190 (21) |
159 (23) |
100 |
NA |
| Cross-reactivity | ||||||||||
| Single high titer | ||||||||||
| JCV | 18 | 6 | ND | 7 | 4 | 3 | NA | 38 (5.4) | 23.8 | NA |
| SSHV | ND | ND | ND | ND | ND | ND | NA | 0 | 0 | NA |
| LACV | ND | ND | ND | ND | ND | 10 | NA | 10 (1) | 6.2 | NA |
| CEV | 4 | 1 | ND | 5 | 4 | 4 | NA | 18 (3) | 11.3 | NA |
| TVTV | 1 | 2 | ND | 1 | 2 | NA | 6 (1) | 3.8 | NA | |
| CVV | ND | ND | ND | ND | ND | ND | NA | 0 | 0 | NA |
| Dual or triple high titers† | ||||||||||
| Total no. | 32 | 12 | ND | 22 | 9 | 12 | NA | 87 (12) | 54.7 | 100 |
| JCV + SSHV | ND | ND | ND | ND | ND | ND | NA | 0 | 0 | 0 |
| JCV + LACV | 1 | ND | ND | 1 | ND | 1 | NA | 3 (0.4) | 1.9 | 3.4 |
| JCV + CEV | 13 | 2 | ND | 8 | 6 | 4 | NA | 33 (4.8) | 20.7 | 37.9 |
| JCV + TVTV | 7 | ND | ND | 7 | ND | ND | NA | 14 (2) | 8.8 | 16.1 |
| SSHV + LACV | ND | ND | ND | ND | ND | ND | NA | 0 | 0 | 0 |
| SSHV + CEV | 1 | ND | ND | 1 | 1 | ND | NA | 3 (0.4) | 1.9 | 1 |
| LACV + CEV | 1 | ND | ND | ND | 1 | ND | NA | 2 (0.2) | 1.2 | 2.3 |
| LACV + TVTV | ND | ND | ND | ND | ND | 2 | NA | 2 (0.2) | 1.2 | 2.3 |
| CEV + TVTV | ND | ND | ND | ND | ND | ND | NA | 0 | 0 | 0 |
| Triple | 9 | 10 | ND | 5 | 1 | 5 | NA | 30 (4.3) | 18.9 | 34.5 |
*Values are no. (%) except as indicated. CEV, California encephalitis virus; E, East; JCV, James Canyon virus; LACV, La Crosse virus; NA, not applicable; NC, north central; ND, not detected; NW, northwest; SC, south central; SSHV, snowshoe hare virus; SW, south-west; TVTV, Trivittatus virus.
1These first authors contributed equally to this article.
2Current affiliation: Department of Microbiology and Cell Biology, Montana State University, Bozeman, Montana, USA