Volume 31, Number 4—April 2025
Research
Neutralizing Antibodies against California Serogroup Orthobunyaviruses in Human Serum Samples, Montana, USA
Table 1
Positivity of samples tested in a study of neutralizing antibodies against California serogroup orthobunyaviruses in human serum samples, Montana, USA*
| Characteristics | Total | Total – SW2 | % JCV-positive, n = 159 |
% Dual positive samples, n = 87 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Hospital region |
||||||||||
| NW | SW1 | SW2 | NC | SC | E | |||||
| Total samples |
190 |
103 |
212 |
201 |
100 |
100 |
906 |
694 |
NA |
NA |
| JCV-positive |
55 (29) |
21 (20) |
31 (15) |
35 (17) |
17 (17) |
31 (31) |
190 (21) |
159 (23) |
100 |
NA |
| Cross-reactivity | ||||||||||
| Single high titer | ||||||||||
| JCV | 18 | 6 | ND | 7 | 4 | 3 | NA | 38 (5.4) | 23.8 | NA |
| SSHV | ND | ND | ND | ND | ND | ND | NA | 0 | 0 | NA |
| LACV | ND | ND | ND | ND | ND | 10 | NA | 10 (1) | 6.2 | NA |
| CEV | 4 | 1 | ND | 5 | 4 | 4 | NA | 18 (3) | 11.3 | NA |
| TVTV | 1 | 2 | ND | 1 | 2 | NA | 6 (1) | 3.8 | NA | |
| CVV | ND | ND | ND | ND | ND | ND | NA | 0 | 0 | NA |
| Dual or triple high titers† | ||||||||||
| Total no. | 32 | 12 | ND | 22 | 9 | 12 | NA | 87 (12) | 54.7 | 100 |
| JCV + SSHV | ND | ND | ND | ND | ND | ND | NA | 0 | 0 | 0 |
| JCV + LACV | 1 | ND | ND | 1 | ND | 1 | NA | 3 (0.4) | 1.9 | 3.4 |
| JCV + CEV | 13 | 2 | ND | 8 | 6 | 4 | NA | 33 (4.8) | 20.7 | 37.9 |
| JCV + TVTV | 7 | ND | ND | 7 | ND | ND | NA | 14 (2) | 8.8 | 16.1 |
| SSHV + LACV | ND | ND | ND | ND | ND | ND | NA | 0 | 0 | 0 |
| SSHV + CEV | 1 | ND | ND | 1 | 1 | ND | NA | 3 (0.4) | 1.9 | 1 |
| LACV + CEV | 1 | ND | ND | ND | 1 | ND | NA | 2 (0.2) | 1.2 | 2.3 |
| LACV + TVTV | ND | ND | ND | ND | ND | 2 | NA | 2 (0.2) | 1.2 | 2.3 |
| CEV + TVTV | ND | ND | ND | ND | ND | ND | NA | 0 | 0 | 0 |
| Triple | 9 | 10 | ND | 5 | 1 | 5 | NA | 30 (4.3) | 18.9 | 34.5 |
*Values are no. (%) except as indicated. CEV, California encephalitis virus; E, east; JCV, Jamestown Canyon virus; LACV, La Crosse virus; NA, not applicable; NC, north central; ND, not detected; NW, northwest; SC, south central; SSHV, snowshoe hare virus; SW, south-west; TVTV, Trivittatus virus.
1These first authors contributed equally to this article.
2Current affiliation: Department of Microbiology and Cell Biology, Montana State University, Bozeman, Montana, USA
Page created: February 08, 2025
Page updated: March 24, 2025
Page reviewed: March 24, 2025
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