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Volume 31, Number 6—June 2025

Research

Long-Term Clinical Outcomes of Adults Hospitalized for COVID-19 Pneumonia

Ivan O. RosasComments to Author , Alejandra Benitez, James A. McKinnell, Reena Shah, Michael Waters, Bradley D. Hunter, Robert Jeanfreau, Larry Tsai, Margaret Neighbors, Ben Trzaskoma, Rita de Cassia Castro, and Fang Cai
Author affiliation: Baylor College of Medicine, Houston, Texas, USA (I.O. Rosas); Genentech, South San Francisco, California, USA (A. Benitez, L. Tsai, M. Neighbors, B. Trzaskoma, R. de Cassia Castro, F. Cai); Torrance Memorial Medical Center, Torrance, California, USA (J.A. McKinnell); Aga Khan University Hospital, Nairobi, Kenya (R. Shah); Velocity Clinical Research, Chula Vista, California, USA (M. Waters); Intermountain Healthcare, Salt Lake City, Utah, USA (B.D. Hunter); Velocity Clinical Research, New Orleans, Louisiana, USA (R. Jeanfreau)

Main Article

Table 1

Proportion of participants with lung texture abnormalities on HRCT scan in LOPAC study of long-term clinical outcomes of adults hospitalized for COVID-19 pneumonia*

HRCT characteristics No. (%) participants
LOPAC study, baseline LOPAC study, month 12
Participants with >1 lung texture abnormality 91 (52.6) 56 (32.4)
Ground-glass opacification 86 (49.7) 51 (29.5)
Reticular pattern 15 (8.7) 10 (5.8)
Bronchiectasis 12 (6.9) 7 (4.0)
Hyperlucency† 2 (1.2) 2 (1.2)
Honeycombing
0
0
Participants with no lung texture abnormality‡ 71 (41.0) 62 (35.8)
Participants with missing data 11 (6.4) 55 (31.8)

*Total number of participants enrolled in the LOPAC study was 173. HRCT, high-resolution computed tomography; LOPAC, Long-Term Outcomes Post Acute COVID-19. †Radiographic evidence of hyperlucency was assessed as unknown in 1 participant’s baseline and month 12 HRCT images. This participant was considered to have radiographic evidence of hyperlucency at baseline and month 12. ‡Participants were considered to have no lung texture abnormality if there was no radiologic evidence of ground-glass opacification, reticular pattern, bronchiectasis, hyperlucency, or honeycombing on HRCT scan.

Main Article

Page created: March 24, 2025
Page updated: May 20, 2025
Page reviewed: May 20, 2025
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