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Volume 31, Number 7—July 2025

CME ACTIVITY - Research

Multicenter Case–Control Study of Behavioral, Environmental, and Geographic Risk Factors for Talaromycosis, Vietnam

Lottie Brown1Comments to Author , Brian Jonat1, Vo Trieu Ly, Nguyen Le Nhu Tung, Pham Si Lam, Nguyen Tat Thanh, Dang Thi Ngoc Bich, Vu Phuong Thao, Nguyen Thi Mai Thu, Ngo Thi Hoa, and Thuy LeComments to Author 
Author affiliation: City St. George’s Hospital and St. George’s University, London, UK (L. Brown); Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA (B. Jonat); Tropical Medicine Research Center for Talaromycosis, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam (V.T. Ly, N.T. Hoa, T. Le); Hospital for Tropical Diseases, Ho Chi Minh City (V.T. Ly, N.L.N. Tung); Oxford University Clinical Research Unit, Ho Chi Minh City (P.S. Lam, N.T. Thanh, N.T. Hoa); National Hospital for Tropical Diseases, Hanoi, Vietnam (D.T.N. Bich); Saskatchewan Cancer Agency, Regina, Saskatchewan, Canada (V.P. Thao); Duke University Medical Center, Durham, North Carolina, USA (N.T.M. Thu, T. Le)

Main Article

Figure

Geographic distribution of recruited cases and controls in multicenter study of behavioral, environmental, and geographic risk factors for talaromycosis, Vietnam. A) Municipal regions of Vietnam, showing topography and locations of recruitment centers in Hanoi and Ho Chi Minh City; B) number of cases by region; C) number of controls by region; D) ratio of cases to controls by region. Darker color represents a higher number of cases relative to controls for that region. A case-to-control ratio of 0.5 is expected because 2 controls were recruited for every case. A ratio <0.5 indicates a lower-than-expected number of cases relative to controls. A ratio >0.5 indicates a greater-than-expected number of cases relative to controls. Data for northern regions of Vietnam are excluded from panel D because study enrollment from these regions was insufficient to draw meaningful conclusions from the analysis. Both cases and controls are concentrated in Southern Vietnam, where most participants were recruited. The ratios of cases to controls are higher in the Central Highlands and the adjacent Southeast and South-Central Coast regions than in Ho Chi Minh City and the Mekong Delta; the highest ratio was seen in the Central Highlands region.

Figure. Geographic distribution of recruited cases and controls in multicenter study of behavioral, environmental, and geographic risk factors for talaromycosis, Vietnam. A) Municipal regions of Vietnam, showing topography and locations of recruitment centers in Hanoi and Ho Chi Minh City; B) number of cases by region; C) number of controls by region; D) ratio of cases to controls by region. Darker color represents a higher number of cases relative to controls for that region. A case-to-control ratio of 0.5 is expected because 2 controls were recruited for every case. A ratio <0.5 indicates a lower-than-expected number of cases relative to controls. A ratio >0.5 indicates a greater-than-expected number of cases relative to controls. Data for northern regions of Vietnam are excluded from panel D because study enrollment from these regions was insufficient to draw meaningful conclusions from the analysis. Both cases and controls are concentrated in Southern Vietnam, where most participants were recruited. The ratios of cases to controls are higher in the Central Highlands and the adjacent Southeast and South-Central Coast regions than in Ho Chi Minh City and the Mekong Delta; the highest ratio was seen in the Central Highlands region.

Main Article

1These authors contributed equally to this article.

Page created: June 23, 2025
Page updated: June 23, 2025
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