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Volume 31, Number 9—September 2025
Dispatch
Related Melioidosis Cases with Unknown Exposure Source, Georgia, USA, 1983–2024
Table
Characteristics, clinical findings, and timeline of events among 4 patients with related melioidosis infections, Georgia, USA, 1983–2024*
Characteristics | Patient 1 | Patient 2 | Patient 3 | Patient 4 |
---|---|---|---|---|
Preceding weather event (strength†) | Hurricane Helene (Category 4) | Hurricane Hugo (Category 4) | None | |
Weather event date | 2024 Sep 26 | 2024 Sep 26 | 1989 Sep 22 | None |
Symptom onset date(s) | 2024 Sep 28 | 2024 Sep 29 | 1989 Oct 5 | Unknown |
Hospitalization admission date |
2024 Oct 2 |
2024 Oct 1 |
Unknown |
Unknown |
Laboratory findings at admission (reference range) | ||||
Leukocyte count (4–11 × 109/L) | 14.98 | 5.92 | Unknown | Unknown |
Neutrophils (39.4%–72.5%) | 77.8% | 82.5% | Unknown | Unknown |
Platelet count (140–400 × 109/L) | 162 | 73 | Unknown | Unknown |
AST (15–37 U/L) | 37 | 193 | Unknown | Unknown |
ALT (16–61 U/L) |
76 |
79 |
Unknown |
Unknown |
Imaging findings at admission |
Chest radiograph: unremarkable; persistent nodule/density in left mid-lung zone. CT abdomen and pelvis with IV contrast: unremarkable |
Chest radiograph: pneumonia with nodule in left lung, suspected bronchogenic neoplasm. CT abdomen and pelvis without contrast: unremarkable |
Unknown |
Unknown |
Comorbidities | None identified | None identified | Diabetes | None identified |
Outcome | Discharged | Discharged | Died | Died |
Discharge or death date | 2024 Oct 16 | 2024 Oct 20 | 1989 October | 1983 October |
Hospital readmission date |
None |
2024 Nov 9 |
None |
None |
Laboratory findings at readmission (reference range) | ||||
Leukocyte count (4–11 × 109/L) | NA | 12.5 | NA | NA |
AST (15–37 U/L) | NA | 705 | NA | NA |
ALT (16–61 U/L) |
NA |
500 |
NA |
NA |
Imaging findings at readmission |
NA |
Chest radiograph: negative for consolidation. CT abdomen and pelvis without contrast: enlarged, edematous prostate consistent with prostatitis |
NA |
NA |
Readmission outcome | NA | Discharged | NA | NA |
Readmission discharge or death date | NA | 2024 Nov 15 | NA | NA |
International travel history (year) | NA | Bahamas (2022) | Unknown | South Korea (1950s), Vietnam (1960s) |
United States military service history | NA | None | World War II | World War II, Korean War, Vietnam War |
*ALT, alanine aminotransferase; AST, aspartate transferase; CT, computed tomography; IV, intravenous; NA, not applicable. †Hurricane category according to the Saffir-Simpson Hurricane Wind Scale (10).
References
- Meumann EM, Limmathurotsakul D, Dunachie SJ, Wiersinga WJ, Currie BJ. Burkholderia pseudomallei and melioidosis. Nat Rev Microbiol. 2024;22:155–69. DOIPubMedGoogle Scholar
- Currie BJ, Mayo M, Ward LM, Kaestli M, Meumann EM, Webb JR, et al. The Darwin Prospective Melioidosis Study: a 30-year prospective, observational investigation. Lancet Infect Dis. 2021;21:1737–46. DOIPubMedGoogle Scholar
- Centers for Disease Control and Prevention. National diabetes statistics report 2024 [cited 2025 Jun 19]. https://www.cdc.gov/diabetes/php/data-research/index.html#cdc_report_pub_study_section_3-prevalence-of-diagnosed-diabetes
- Petras JK, Elrod MG, Ty M, Adams P, Zahner D, Adams A, et al. Notes from the field: Burkholderia pseudomallei detected in a raccoon carcass linked to a multistate aromatherapy-associated melioidosis outbreak—Texas, 2022. MMWR Morb Mortal Wkly Rep. 2022;71:1597–8. DOIPubMedGoogle Scholar
- Hall CM, Romero-Alvarez D, Martz M, Santana-Propper E, Versluis L, Jiménez L, et al. Low risk of acquiring melioidosis from the environment in the continental United States. PLoS One. 2022;17:
e0270997 . DOIPubMedGoogle Scholar - Petras JK, Elrod MG, Ty MC, Dawson P, O’Laughlin K, Gee JE, et al. Locally acquired melioidosis linked to environment—Mississippi, 2020–2023. N Engl J Med. 2023;389:2355–62. DOIPubMedGoogle Scholar
- Limmathurotsakul D, Golding N, Dance DA, Messina JP, Pigott DM, Moyes CL, et al. Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis. Nat Microbiol. 2016;1:15008. DOIGoogle Scholar
- Cheng AC, Jacups SP, Gal D, Mayo M, Currie BJ. Extreme weather events and environmental contamination are associated with case-clusters of melioidosis in the Northern Territory of Australia. Int J Epidemiol. 2006;35:323–9. DOIPubMedGoogle Scholar
- Guendel I, Ekpo LL, Hinkle MK, Harrison CJ, Blaney DD, Gee JE, et al. Melioidosis after Hurricanes Irma and Maria, St. Thomas/St. John District, US Virgin Islands, October 2017. Emerg Infect Dis. 2019;25:1952–5. DOIPubMedGoogle Scholar
- National Hurricane Center and Central Pacific Hurricane Center. Tropical cyclone climatology. [cited 2025 Feb 26]. https://www.nhc.noaa.gov/climo
- Peacock SJ, Schweizer HP, Dance DA, Smith TL, Gee JE, Wuthiekanun V, et al. Management of accidental laboratory exposure to Burkholderia pseudomallei and B. mallei. Emerg Infect Dis. 2008;14:
e2 . DOIPubMedGoogle Scholar - Didelot X, Wilson DJ. ClonalFrameML: efficient inference of recombination in whole bacterial genomes. PLoS Comput Biol. 2015;11:
e1004041 . DOIPubMedGoogle Scholar - Treangen TJ, Ondov BD, Koren S, Phillippy AM. The Harvest suite for rapid core-genome alignment and visualization of thousands of intraspecific microbial genomes. Genome Biol. 2014;15:524. DOIPubMedGoogle Scholar
- Howes M, Currie BJ. Melioidosis and activation from latency: the “time bomb” has not occurred. Am J Trop Med Hyg. 2024;111:156–60. DOIPubMedGoogle Scholar
- Webb JR, Buller N, Rachlin A, Golledge C, Sarovich DS, Price EP, et al. A persisting nontropical focus of Burkholderia pseudomallei with limited genome evolution over five decades. mSystems. 2020;5:e00726–20. DOIPubMedGoogle Scholar
1These first authors contributed equally to this article.
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