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Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.

Volume 32, Number 1—January 2026

Research

Reduced Emergency Department Visits and Hospitalizations in Infants after Universal Respiratory Syncytial Virus Immunization, Italy, 2024–25

Simone Villa1Comments to Author , Simona Scarioni1, Enrico Pigozzi, Manuel Maffeo, Mauro Maistrello, Giorgio Bagarella, Francesco Scovenna, Federica Morani, Marlen Romano, Gianvincenzo Zuccotti, Massimo Agosti, Catia Borriello, Elena Pariani, Guido Bertolaso, Luigi Vezzosi, Fausto Baldanti, Mario Melazzini, Elena Azzolini, Gabriele del Castillo2, Danilo Cereda2, and Regional Immunization Council3
Author affiliation: Directorate General for Health, Lombardy Region, Milan, Italy (S. Villa, S. Scarioni, E. Pigozzi, M. Maffeo, M. Maistrello, G. Bagarella, F. Scovenna, F. Morani, C. Borriello, G. Bertolaso, L. Vezzosi, M. Melazzini, G. del Castillo, D. Cereda); University of Milan, Milan (S. Villa, S. Scarioni, E. Pigozzi, F. Scovenna, G. Zuccotti, E. Pariani); Regional Company for Innovation and Purchasing Aria S.p.A., Milan (M. Romano); Buzzi Children’s Hospital, Milan (G. Zuccotti); Hospital “F. Del Ponte,” University of Insubria, Varese, Italy (M. Agosti); Fondazione IRCCS Policlinico San Matteo, Pavia, Italy (F. Baldanti); University of Pavia, Pavia (F. Baldanti); Humanitas University, Pieve Emanuele, Italy (E. Azzolini)

Main Article

Figure 2

EDVs and hospitalizations in children 1–5 years of age in study of reduced EDVs and hospitalizations in infants after universal respiratory syncytial virus immunization, Italy, 2024–25. Numbers are shown for ISO week 35–2018 to ISO week 19–2025 for lower respiratory tract infection (A) and respiratory syncytial virus infections (B). Green shading indicates the period during which public health and social measures were implemented in response to the initial waves of the COVID-19 pandemic in the region. Red shading marks the prophylaxis period during which nirsevimab was administered. EDV, emergency department visit.

Figure 2. EDVs and hospitalizations in children 1–5 years of age in study of reduced EDVs and hospitalizations in infants after universal respiratory syncytial virus immunization, Italy, 2024–25. Numbers are shown for ISO week 35–2018 to ISO week 19–2025 for lower respiratory tract infection (A) and respiratory syncytial virus infections (B). Green shading indicates the period during which public health and social measures were implemented in response to the initial waves of the COVID-19 pandemic in the region. Red shading marks the prophylaxis period during which nirsevimab was administered. EDV, emergency department visit.

Main Article

1These authors contributed equally to this article and share first authorship.

2These authors contributed equally to this article and share last authorship.

3Members of the Regional Immunization Council are listed at the end of this article.

Page created: December 13, 2025
Page updated: January 07, 2026
Page reviewed: January 07, 2026
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