Emergence of New Delhi Metallo-β-Lactamase 14–Producing Klebsiella pneumoniae Sequence Type 147 Clone in Spain and Outbreak in the Canary Islands
Pablo Aja-Macaya
1, Tania Blanco-Martín
1, Cristian Mateo-León
1, Cristóbal del Rosario-Quintana, Carmen Piña, Enrique de la Cruz-Tabares, Salud Rodríguez-Pallares, Lucía González-Pinto, Alejandro Beceiro, Marina Oviaño, Germán Bou, Diego García-Martínez de Artola
2, and Jorge Arca-Suárez
2
Author affiliation: Servicio de Microbiología Clínica and Instituto de Investigación Biomédica A Coruña (INIBIC), Complexo Hospitalario Universitario, A Coruña, Spain (P. Aja-Macaya, T. Blanco-Martín, S. Rodríguez-Pallares, L. González-Pinto, A. Beceiro, M. Oviaño, G. Bou, J. Arca-Suárez); CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain (T. Blanco-Martín, A. Beceiro, M. Oviaño, G. Bou, J. Arca-Suárez); Hospital Universitario Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain (C. Mateo-León, D. García-Martínez de Artola); Complejo Hospitalario Universitario Insular-Materno Infantil de Gran Canaria, Las Palmas de Gran Canaria, Spain (C. del Rosario-Quintana, C. Piña); Complejo Hospitalario Universitario Insular-Materno Infantil de Gran Canaria, Las Palmas de Gran Canaria (Enrique de la Cruz-Tabares)
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Figure 3
Figure 3. Comparison of 2 of the most relevant plasmids in isolates from study of emergence of New Delhi metallo-β-lactamase (NDM) 14–producing Klebsiella pneumoniae ST147 clone in Spain and outbreak in the Canary Islands. The blaNDM-14–containing plasmid pNDM-14 (A) and its probable helper for conjugation and intraspecies transmission pHelper (B) are shown, comparing multiple K. pneumoniae ST147 strains from different countries (Spain, I238; France, 296B5 and 320G1; United Kingdom, KP88; the Netherlands, C055099) and a phylogenomically distant K. pneumoniae ST997 carrying the same plasmids (I542, Spain). The outer ring shows loci, including resistance genes and conjugative transfer proteins. Because of the large size of pHelper, only those 2 types of features are shown. The other rings represent the presence or absence of parts of the plasmid relative to the I238 reference plasmid. ESP, Spain; FRA, France; GBR, United Kingdom; Inc, incompatibility group; NLD, the Netherlands; ST, sequence type.
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