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Volume 32, Number 4—April 2026

Research

Transmissibility and Disease Progression of Asymptomatic Mycobacterium tuberculosis Infection, Lima, Peru

Ruitong Wang, Chuan-Chin Huang, Mercedes C. Becerra, Roger I. Calderon, Carmen C. Contreras, Jerome T. Galea, Judith Jimenez, Leonid Lecca, Rosa M. Yataco, Zibiao Zhang, and Megan B. MurrayComments to Author 
Author affiliation: Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA (R. Wang, M.B. Murray); Harvard Medical School, Boston (C.-C. Huang, M.C. Becerra, L. Lecca, M.B. Murray); Brigham and Women’s Hospital, Boston (C.-C. Huang, Z. Zhang, M.B. Murray); Advanced Research and Health, Lima, Peru (R.I. Calderon); Universidad de San Martin de Porres, Lima (R.I. Calderon); Partners In Health—Socios En Salud Sucursal Peru, Lima (C.C. Contreras, J. Jimenez, L. Lecca, R.M. Yataco); University of South Florida, Tampa, Florida, USA (J.T. Galea)

Main Article

Table 3

Hazard ratios of Mycobacterium tuberculosis infection at 6-month follow-up among initially uninfected household contacts of tuberculosis patients in study of transmissibility of asymptomatic M. tuberculosis infection, Lima, Peru*

Symptom status No. contacts No. (%) incident infection Univariate model
 Multivariate model A†
 Multivariate model B‡
Crude HR (95% CI) p value Adjusted HR (95% CI) p value Adjusted HR (95% CI) p value
Symptomatic 2,204 320 (14.52) Referent Referent Referent
Asymptomatic 68 7 (10.29) 0.63 (0.27–1.49) 0.29 0.62 (0.26–1.51) 0.29 0.62 (0.26–1.51) 0.30

*Household contacts are children <15 years of age. HR, hazard ratio. †Multivariate model A was adjusted for the following characteristics of index patients: age, sex, HIV status, smoking status, alcohol consumption status, socioeconomic status, employment status, and diabetes; and the following characteristics of household contacts: age, sex, HIV status, alcohol consumption status, bacille Calmette–Guérin vaccination, and body mass index category. Diabetes and smoking status of household contacts excluded due to sparse data in some of its categories, which led to unstable hazard ratio estimates and nonestimable coefficients in the Cox model. ‡Multivariate model B did not adjust for sex and alcohol consumption of household contact.

Main Article

Page created: March 10, 2026
Page updated: April 15, 2026
Page reviewed: April 15, 2026
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