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Volume 32, Number 4—April 2026

Research

Transmissibility and Disease Progression of Asymptomatic Mycobacterium tuberculosis Infection, Lima, Peru

Ruitong Wang, Chuan-Chin Huang, Mercedes C. Becerra, Roger I. Calderon, Carmen C. Contreras, Jerome T. Galea, Judith Jimenez, Leonid Lecca, Rosa M. Yataco, Zibiao Zhang, and Megan B. MurrayComments to Author 
Author affiliation: Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA (R. Wang, M.B. Murray); Harvard Medical School, Boston (C.-C. Huang, M.C. Becerra, L. Lecca, M.B. Murray); Brigham and Women’s Hospital, Boston (C.-C. Huang, Z. Zhang, M.B. Murray); Advanced Research and Health, Lima, Peru (R.I. Calderon); Universidad de San Martin de Porres, Lima (R.I. Calderon); Partners In Health—Socios En Salud Sucursal Peru, Lima (C.C. Contreras, J. Jimenez, L. Lecca, R.M. Yataco); University of South Florida, Tampa, Florida, USA (J.T. Galea)

Main Article

Table 2

Risk for Mycobacterium tuberculosis infection at baseline among household contacts of tuberculosis index patients in study of transmissibility of asymptomatic M. tuberculosis infection, Lima, Peru*

Symptom status No. contacts No. (%) baseline infection Univariate model
 Multivariate model A†
 Multivariate model B‡
Crude PR (95% CI) p value Adjusted PR (95% CI) p value Adjusted PR (95% CI) p value
Symptomatic 3,586 824 (22.98) Referent Referent Referent
Asymptomatic 113 17 (15.04) 0.60 (0.36–1.01) 0.06 0.62 (0.37– 1.03) 0.07 0.61 (0.36–1.03) 0.06

*Household contacts are children <15 years of age. PR, prevalence ratio. †Multivariate model A was adjusted for the following characteristics of index patients: age, sex, HIV status, smoking status, alcohol consumption status, socioeconomic status, employment status, and diabetes; and the following characteristics of household contacts: age, sex, smoking status, alcohol consumption status, bacille Calmette–Guérin vaccination, and body mass index category. Diabetes and HIV status of household contacts were excluded due to sparse data in some of its categories, which led to unstable estimates and nonestimable coefficients in the model. ‡Multivariate model B did not adjust for employment status and sex of index patients.

Main Article

Page created: March 10, 2026
Page updated: April 15, 2026
Page reviewed: April 15, 2026
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