Table 5

Volume 32, Number 4—April 2026

Transmissibility and Disease Progression of Asymptomatic Mycobacterium tuberculosis Infection, Lima, Peru

Ruitong Wang, Chuan-Chin Huang, Mercedes C. Becerra, Roger I. Calderon, Carmen C. Contreras, Jerome T. Galea, Judith Jimenez, Leonid Lecca, Rosa M. Yataco, Zibiao Zhang, and Megan B. Murray

Author affiliation: Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA (R. Wang, M.B. Murray); Harvard Medical School, Boston (C.-C. Huang, M.C. Becerra, L. Lecca, M.B. Murray); Brigham and Women’s Hospital, Boston (C.-C. Huang, Z. Zhang, M.B. Murray); Advanced Research and Health, Lima, Peru (R.I. Calderon); Universidad de San Martin de Porres, Lima (R.I. Calderon); Partners In Health—Socios En Salud Sucursal Peru, Lima (C.C. Contreras, J. Jimenez, L. Lecca, R.M. Yataco); University of South Florida, Tampa, Florida, USA (J.T. Galea)

Main Article

Risk for Mycobacterium tuberculosis infection at baseline among household contacts of tuberculosis index patients by symptom pattern in study of transmissibility of asymptomatic M. tuberculosis infection, Lima, Peru*

Symptom status†	No. contacts	No. (%) baseline infection	Univariate model		Multivariate model A‡		Multivariate model B§
Symptom status†	No. contacts	No. (%) baseline infection	Crude PR (95% CI)	p value	Adjusted PR (95% CI)	p value	Adjusted PR (95% CI)	p value
Asymptomatic	113	17 (15.04)	Referent		Referent		Referent
Cough only	296	68 (22.97)	1.64 (0.92–2.90)	0.09	1.59 (0.90–2.80)	0.11	1.61 (0.92–2.82)	0.10
Noncough symptoms only	266	33 (12.41)	0.94 (0.51–1.73)	0.83	0.94 (0.51–1.72)	0.83	0.95 (0.52–1.75)	0.87
Cough and any noncough symptoms	2,964	712 (24.02)	1.73 (1.03–2.90)	0.04	1.67 (1.00–2.78)	0.05	1.68 (1.01–2.79)	0.05

*Household contacts are children <15 years of age. PR, prevalence ratio. †Noncough symptoms include fever, weight loss and night sweats. ‡Multivariate model A was adjusted for the following characteristics of index patients: age, sex, HIV status, smoking status, alcohol consumption status, socioeconomic status, employment status, and diabetes; and the following characteristics of household contacts: age, sex, smoking status, alcohol consumption status, bacille Calmette–Guérin vaccination, and body mass index category. Diabetes and HIV status of household contacts excluded due to sparse data in some of its categories, which led to unstable estimates and nonestimable coefficients in the model. §Multivariate model B did not adjust for employment status of index patients and sex, bacille Calmette–Guérin scar, alcohol consumption, and body mass index category of household contacts.

Main Article

Page created: March 10, 2026

Page updated: April 15, 2026

Page reviewed: April 15, 2026

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