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Volume 32, Number 4—April 2026

Research

Transmissibility and Disease Progression of Asymptomatic Mycobacterium tuberculosis Infection, Lima, Peru

Ruitong Wang, Chuan-Chin Huang, Mercedes C. Becerra, Roger I. Calderon, Carmen C. Contreras, Jerome T. Galea, Judith Jimenez, Leonid Lecca, Rosa M. Yataco, Zibiao Zhang, and Megan B. MurrayComments to Author 
Author affiliation: Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA (R. Wang, M.B. Murray); Harvard Medical School, Boston (C.-C. Huang, M.C. Becerra, L. Lecca, M.B. Murray); Brigham and Women’s Hospital, Boston (C.-C. Huang, Z. Zhang, M.B. Murray); Advanced Research and Health, Lima, Peru (R.I. Calderon); Universidad de San Martin de Porres, Lima (R.I. Calderon); Partners In Health—Socios En Salud Sucursal Peru, Lima (C.C. Contreras, J. Jimenez, L. Lecca, R.M. Yataco); University of South Florida, Tampa, Florida, USA (J.T. Galea)

Main Article

Table 4

Hazard ratios of incident tuberculosis disease among all household contacts of index patients by symptom status in study of transmissibility of asymptomatic M. tuberculosis infection, Lima, Peru*

Symptom status No. contacts No. (%) incident disease Univariate model
 Multivariate model A†
 Multivariate model B
Crude HR (95% CI) p value Adjusted HR (95% CI) p value Adjusted HR (95% CI) p value
Symptomatic 10,375 313 (3.02) Referent Referent Referent
Asymptomatic 410 10 (2.44) 0.74 (0.35–1.56) 0.43 0.80 (0.38–1.67) 0.55 0.81 (0.39–1.69) 0.57

* Household contacts are children <15 years of age. HR, hazard ratio. †Multivariate model A was adjusted for the following characteristics of index patients: age, sex, HIV status, smoking status, alcohol consumption status, socioeconomic status, employment status, and diabetes; and the following characteristics of household contacts: age, sex, HIV status, smoking status, alcohol consumption status, diabetes, bacille Calmette–Guérin vaccination, and body mass index category. ‡Multivariate model B did not adjust for employment status of index patient, and sex, smoking status, and alcohol consumption of household contacts

Main Article

Page created: March 10, 2026
Page updated: April 15, 2026
Page reviewed: April 15, 2026
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