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Volume 32, Number 5—May 2026

Dispatch

Tropism and Replication Competence of Cattle Influenza A(H5N1) Genotype B3.13 Virus in Human Bronchus and Lung Tissue

Kenrie P.Y. Hui, John C.W. Ho, Ka-Chun Ng, Richard J. Webby, Malik Peiris, John M. Nicholls, and Michael C.W. ChanComments to Author 
Author affiliation: Centre for Immunology & Infection, Hong Kong, China (K.P.Y. Hui, J.C.W. Ho, M. Peiris, M.C.W. Chan); School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong (K.P.Y. Hui, K.-C. Ng, M. Peiris, M.C.W. Chan); St. Jude Children’s Research Hospital, Memphis, Tennessee, USA (R.J. Webby); School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong (J.M. Nicholls)

Main Article

Figure 3

Cytokine and chemokine mRNA expressions in a study of tropism and replication competence of cattle influenza A(H5N1) genotype B3.13 virus in human lung tissue. A) Matrix gene; B) IFNA1; C) IFNB1; D) CXCL10; E) ISG15; F) CCL2; G) IFIH1; H) CCL5; I) RIGI; J) TNF. Expressions measured at 48 hours postinfection. Data were pooled from >3 independent experiments. Bars indicate mean, whiskers indicate SD. Statistical significance was calculated by using 1-way analysis of variance with Tukey posthoc test. Statistical significance is in comparison with mock. ACTB, beta-actin; CCL, C-C motif chemokine ligand; CXCL, C-X-C motif chemokine ligand; IFIH, interferon induced with helicase C domain; IFNA, interferon alpha; IFNB, interferon beta; ISG, interferon-stimulated gene; RIGI, retinoic acid–inducible gene; TNF, tumor necrosis factor.

Figure 3. Cytokine and chemokine mRNA expressions in a study of tropism and replication competence of cattle influenza A(H5N1) genotype B3.13 virus in human lung tissue. A) Matrix gene; B) IFNA1; C) IFNB1; D) CXCL10; E) ISG15; F) CCL2; G) IFIH1; H) CCL5; I) RIGI; J) TNF. Expressions measured at 48 hours postinfection. Data were pooled from >3 independent experiments. Bars indicate mean, whiskers indicate SD. Statistical significance was calculated by using 1-way analysis of variance with Tukey posthoc test. Statistical significance is in comparison with mock. ACTB, beta-actin; CCL, C-C motif chemokine ligand; CXCL, C-X-C motif chemokine ligand; IFIH, interferon induced with helicase C domain; IFNA, interferon alpha; IFNB, interferon beta; ISG, interferon-stimulated gene; RIGI, retinoic acid–inducible gene; TNF, tumor necrosis factor.

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Page created: March 24, 2026
Page updated: May 07, 2026
Page reviewed: May 07, 2026
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