Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link

Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.

Volume 32, Number 7—July 2026

Research

National Surveillance of Enterovirus D68 Upsurge, France, 2024

Marion Jeannoël, Maxime Bisseux, Stéphanie Dan, Elisa Creuzet, Delphine Parraud, Jean-Luc Bailly, Jérémie Lebeurre, Amélie Brebion, Hélène Chabrolles, Laurence Josset, Cécile Henquell, Isabelle Schuffenecker, Audrey MirandComments to Author , and Enterovirus Surveillance Network1
Author affiliation: Hospices Civils de Lyon, Centre National de Référence des Entérovirus–Laboratoire Associé, Lyon, France (M. Jeannoël, S. Dan, D. Parraud, J. Lebeurre, L. Josset, I. Schuffenecker); Université Clermont Auvergne, Clermont-Ferrand (M. Bisseux, E. Creuzet, H. Chabrolles, C. Henquell, A. Mirand); Centre Hospitalier Universitaire de Clermont-Ferrand, Centre National de Référence des Entérovirus–Laboratoire Coordonnateur, Clermont-Ferrand, France (M. Bisseux, A. Brebion, H. Chabrolles, A. Mirand); Université Claude Bernard Lyon 1, Villeurbanne, France (S. Dan, D. Parraud, L. Josset); Université Clermont Auvergne, Clermont-Ferrand (J. Bailly)

Main Article

Figure 9

Structural models of the capsid pentamer of the newly identified A2 clade of enterovirus D68, from report on national surveillance of enterovirus upsurge, France, 2021–2024. On the basis of a consensus sequence of the newly identified A2 clade, we reconstructed pentameric capsid subunit using AlphaFold (https://alphafoldserver.com) and validated it by structural comparison with the crystal structure of the reference enterovirus D68 strain (structure 4WM8; RCSB Protein Data Bank, https://www.rcsb.org). A) Outer surface view. B) Side view. Structural models of the capsid pentamer are shown with proteins colored as follows: orange, viral protein (VP) 1; green, VP2; blue, VP3; white, VP4. Red indicates amino acid substitutions.

Figure 9. Structural models of the capsid pentamer of the newly identified A2 clade of enterovirus D68, from report on national surveillance of enterovirus upsurge, France, 2021–2024. On the basis of a consensus sequence of the newly identified A2 clade, we reconstructed pentameric capsid subunit using AlphaFold (https://alphafoldserver.com) and validated it by structural comparison with the crystal structure of the reference enterovirus D68 strain (structure 4WM8; RCSB Protein Data Bank, https://www.rcsb.org). A) Outer surface view. B) Side view. Structural models of the capsid pentamer are shown with proteins colored as follows: orange, viral protein (VP) 1; green, VP2; blue, VP3; white, VP4. Red indicates amino acid substitutions.

Main Article

1Additional members of Enterovirus Surveillance Network who contributed data are listed at the end of this article.

Page created: April 30, 2026
Page updated: June 04, 2026
Page reviewed: June 04, 2026
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external