Volume 12, Number 9—September 2006
Research
Genomic Signatures of Human versus Avian Influenza A Viruses
Guang-Wu Chen*1, Shih-Cheng Chang*1, Chee-Keng Mok*, Yu-Luan Lo*, Yu-Nong Kung*, Ji-Hung Huang*, Yun-Han Shih*, Ji-Yi Wang*, Chiayn Chiang*, Chi-Jene Chen*, and Shin-Ru Shih*
Table 2
Summary of host-associated amino acid signature changes
| Gene | Position | Residue* | H5N1 | H9N2 | H7N2 | H7N7 |
|---|---|---|---|---|---|---|
| PB2 | 199 | A(19) | 15 | 3 | 1 | |
| S(5) | 5 | |||||
| 271 | T(23) | 20 | 2 | 1 | ||
| A(1) | 1 | |||||
| 627 | E(22) | 19 | 3 | |||
| K(7) | 6 | 1 | ||||
| PB1-F2 | 73 | K(24) | 17 | 2 | 5 | |
| R(2) | 2 | |||||
| 79 | R(24) | 17 | 2 | 5 | ||
| Q(2) | 2 | |||||
| 82 | L(21) | 19 | 2 | |||
| S(5) | 5 | |||||
| PA | 409 | S(17) | 12 | 3 | 2 | |
| N(7) | 7 | |||||
| M2 | 20 | S(34) | 31 | 2 | 1 | |
| N(5) | 5 | |||||
| NS2 | 70 | S(26) | 22 | 2 | 2 | |
| G(1) | 1 |
*Top half displays an avian-specific residue with the count in parentheses and distribution among subtypes, and the bottom half represents a human-specific residue.
1These authors contributed equally to this article.
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