Volume 12, Number 9—September 2006
Research
Genomic Signatures of Human versus Avian Influenza A Viruses
Guang-Wu Chen*1, Shih-Cheng Chang*1, Chee-Keng Mok*, Yu-Luan Lo*, Yu-Nong Kung*, Ji-Hung Huang*, Yun-Han Shih*, Ji-Yi Wang*, Chiayn Chiang*, Chi-Jene Chen*, and Shin-Ru Shih*
Table A4
Amino acid 'signatures' validation. Only positions with both newly computed entropy values less or equal to -0.400 are considered 'validated'. This reduces 228 signatures to a count of 52 (the ones shown in bold face) as reported in the manuscript. Cnt: total number of avian or human residues at this position; Ent: computed entropy value; PR8: position numbering based on PR8 (only HA and NA have different numbering here). Full table available at www.cdc.gov/eid-static/spreadsheets/06-0276-TA4.xlsx.
| Gene | Pos | Avian influenza viruses |
Human influenza viruses |
Validated? | PR8 | ||||
|---|---|---|---|---|---|---|---|---|---|
| Cnt | Ent | Residues | Cnt | Ent | Residues | ||||
| PB2 | 44 | 215 | -0.144 | A(208),S(7), | 843 | -0.081 | A(10),L(2),S(831), | Yes | |
| 67 | 215 | -0.174 | I(206),V(9), | 843 | -0.538 | I(193),V(650), | |||
| 81 | 215 | -0.196 | A(2),I(7),T(206), | 843 | -0.537 | I(2),L(4),M(686),T(4),V(147), | |||
| 82 | 215 | -0.164 | R(1),N(209),K(1),S(2),T(2), | 843 | -0.608 | N(180),C(14),S(648),X(1), | |||
| 120 | 215 | 0.000 | E(215), | 843 | -0.575 | N(1),D(628),E(214), | |||
| 199 | 215 | -0.110 | A(210),S(5), | 845 | -0.024 | A(3),S(842), | Yes | ||
| 227 | 215 | 0.000 | V(215), | 845 | -0.697 | I(586),M(19),V(240), | |||
| 271 | 215 | -0.133 | A(3),I(1),M(1),T(210), | 843 | -0.051 | A(836),S(1),T(6), | Yes | ||
| 382 | 215 | -0.110 | I(210),V(5), | 842 | -0.527 | I(185),V(657), | |||
| 453 | 215 | -0.164 | Q(2),H(1),L(2),P(209),S(1), | 842 | -0.497 | R(1),H(691),L(1),P(147),S(2), | |||
| 456 | 215 | -0.219 | N(205),D(6),S(4), | 842 | -0.623 | N(247),D(1),C(1),S(593), | |||
| 461 | 215 | -0.159 | I(207),V(8), | 842 | -0.638 | I(283),V(559), | |||
| 463 | 215 | -0.247 | I(203),L(1),M(1),V(10), | 842 | -0.529 | I(181),M(1),V(660), | |||
| 475 | 215 | -0.030 | L(214),M(1), | 842 | -0.024 | L(3),M(839), | Yes | ||
| 478 | 215 | -0.484 | I(30),L(1),M(2),V(182), | 842 | -0.541 | I(656),L(2),V(184), | |||
| 526 | 215 | -0.053 | R(2),K(213), | 841 | -0.577 | R(619),K(222), | |||
| 559 | 215 | -0.255 | I(5),M(2),T(204),V(4), | 841 | -0.694 | A(547),N(1),I(2),T(287),V(4), | |||
| 588 | 215 | -0.254 | A(203),T(6),V(6), | 841 | -0.050 | A(2),I(835),V(3),X(1), | Yes | ||
| 613 | 215 | -0.073 | A(3),V(212), | 841 | -0.157 | A(8),I(16),T(816),V(1), | Yes | ||
| 627 | 215 | -0.299 | E(196),K(19), | 841 | -0.026 | R(2),E(1),K(838), | Yes | ||
1These authors contributed equally to this article.
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