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Volume 15, Number 9—September 2009


Susceptibilities of Nonhuman Primates to Chronic Wasting Disease

Brent Race1Comments to Author , Kimberly D. Meade-White1, Michael W. Miller, Kent D. Barbian, Richard Rubenstein, Giuseppe LaFauci, Larisa Cervenakova, Cynthia Favara, Donald Gardner, Dan Long, Michael Parnell, James Striebel, Suzette A. Priola, Anne Ward, Elizabeth S. Williams2, Richard Race3, and Bruce Chesebro3
Author affiliations: Rocky Mountain Laboratories, Hamilton, Montana, USA (B. Race, K.D. Meade-White, K.D. Barbian, C. Favara, D. Gardner, D. Long, M. Parnell, J. Striebel, S.A. Priola, A. Ward, R. Race, B. Chesebro); Colorado Division of Wildlife, Fort Collins, Colorado, USA (M.W. Miller); State University of New York Downstate Medical Center, Brooklyn, New York, USA (R. Rubenstein); New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA (G. LaFauci); American Red Cross, Rockville, Maryland, USA (L. Cervenakova); University of Wyoming, Laramie, Wyoming, USA (E.S. Williams)

Main Article

Table 4

PrP sequence variability in squirrel monkeys*

Genotype† No. monkeys PrP gene variations‡
Residue 19 No. octapeptide repeats Residue 164
A 16 Leu/Leu 5/5 Lys/Lys
B 5 ND 4/5 Lys/Lys
C 2 Val/Leu 5/5 Lys/Lys
Schätzl 1 Leu/Leu 5/5 Arg/Arg
Schneider 1 ND 4/4 Arg/Arg

*PrP, prion protein; ND, not determined.
†The PrP genes of 23 monkeys were sequenced, and 3 genotypes were found. For easy reference to Tables 1 and 2, they are designated types A, B, and C. Previous squirrel monkey PrP sequences were identified by Schätzl et al. (28) and Schneider et al. (31).
‡Compared with published sequences, PrP genotype variations were seen only at residue 19 (in the signal peptide), residue 164, and in the number of octapeptide repeats.

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1These authors contributed equally to this article.


3Co-senior authors.