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Volume 15, Number 9—September 2009


Susceptibilities of Nonhuman Primates to Chronic Wasting Disease

Brent Race1Comments to Author , Kimberly D. Meade-White1, Michael W. Miller, Kent D. Barbian, Richard Rubenstein, Giuseppe LaFauci, Larisa Cervenakova, Cynthia Favara, Donald Gardner, Dan Long, Michael Parnell, James Striebel, Suzette A. Priola, Anne Ward, Elizabeth S. Williams2, Richard Race3, and Bruce Chesebro3
Author affiliations: Rocky Mountain Laboratories, Hamilton, Montana, USA (B. Race, K.D. Meade-White, K.D. Barbian, C. Favara, D. Gardner, D. Long, M. Parnell, J. Striebel, S.A. Priola, A. Ward, R. Race, B. Chesebro); Colorado Division of Wildlife, Fort Collins, Colorado, USA (M.W. Miller); State University of New York Downstate Medical Center, Brooklyn, New York, USA (R. Rubenstein); New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA (G. LaFauci); American Red Cross, Rockville, Maryland, USA (L. Cervenakova); University of Wyoming, Laramie, Wyoming, USA (E.S. Williams)

Main Article

Table 3

Cynomolgus macaques infected with CWD agent*

No. monkeys CWD inoculum Route of inoculation Titer inoculated† Current mpi
1 (no. 609)‡ MD-1 Intracerebral 2.5 × 106 NA
1 MD-1 Intracerebral 2.5 × 106 70
3 MD-1 Oral 2.0 × 109 70
2 Elk-1 Intracerebral 3.2 × 105 70
3 Elk-1 Oral 2.5 × 108 70
2 WTD-1 Intracerebral 1.0 × 106 70
3 WTD-1 Oral 1.2 × 109 70

*CWD, chronic wasting disease; mpi, months postinfection; NA, not available.
†Infectivity titers were determined by using endpoint dilution titer in transgenic deer expressing mouse prion protein and are listed as the total 50% infectious dose/g of brain.
‡Monkey 609 was euthanized at 48 mpi, and no protease-resistant prion protein was detected by Western blot or immunohistochemical analysis.

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1These authors contributed equally to this article.


3Co-senior authors.