Volume 18, Number 1—January 2012
Assessing Prion Infectivity of Human Urine in Sporadic Creutzfeldt-Jakob Disease
|Inoculum||Brain† dilution||Incubation time, d, mean ± SEM||Distribution||Prion titer, ID50/g tissue†|
|MF in normal urine, then concentrated 100× and dialyzed||10−2||265 ± 12‡||8/9||8.2 × 106|
|MF in 100× concentrated and dialyzed normal human urine||10−2||268 ± 10‡||8/8||6.9 × 106|
*MF, microsomal fraction; sCJD, sporadic Creutzfeldt-Jakob disease; ID50, 50% infectious dose.
†Brain tissue equivalent.
‡p = 0.42 by t-test.
1These authors contributed equally to this article.
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