Volume 18, Number 1—January 2012
Research
Assessing Prion Infectivity of Human Urine in Sporadic Creutzfeldt-Jakob Disease
Table 1
Infectivity titers in microsomal fraction of 4 patients with sCJDMM1*
sCJDMM1 inoculum | Brain† dilution | Incubation time, d , mean ± SEM | Distribution | Prion titer, ID50/g tissue† |
---|---|---|---|---|
Patient 1 | 10−1 | 256 ± 5 | 7/7 | 3.0 × 106 |
10−2 | 297 ± 18 | 4/4 | ||
10−3 | 314 ± 15 | 5/5 | ||
10−4 | 339 ± 16 | 5/5 | ||
10−5 | 420, 437 | 2/5 | ||
10−6 | >681 | 0/5 | ||
Patient 2 | 10−4 | 382 ± 12 | 5/10 | 2.2 × 106 |
Patient 3 | 10−4 | 348 ± 12 | 10/10 | 1.2 × 107 |
Patient 4 | 10−2 | 267 ± 14 | 5/5 | 7.2 × 106 |
*sCJD, sporadic Creutzfeldt-Jakob disease; ID50, 50% infectious dose.
†Brain tissue equivalent.
1These authors contributed equally to this article.
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