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Volume 18, Number 1—January 2012


Assessing Prion Infectivity of Human Urine in Sporadic Creutzfeldt-Jakob Disease

Silvio Notari1, Liuting Qing1, Maurizio Pocchiari, Ayuna Dagdanova, Kristin Hatcher, Arend Dogterom, Jose F. Groisman, Ib Bo Lumholtz, Maria Puopolo, Corinne Lasmezas, Shu G. Chen, Qingzhong Kong, and Pierluigi GambettiComments to Author 
Author affiliations: Case Western Reserve University, Cleveland, Ohio, USA (S. Notari, L. Qing, A. Dagdanova, K. Hatcher, S.G. Chen, Q. Kong, P. Gambetti); Istituto Superiore di Sanità, Rome, Italy (M. Pocchiari, M. Puopolo); Ferring Pharmaceuticals, Hvidore, Denmark (A. Dogterom); Instituto Massone, Buenos Aires, Argentina (J.F. Groisman); BL Consult ApS, Copenhagen, Denmark (I.B. Lumholtz); The Scripps Research Institute, Jupiter, Florida, USA (C. Lasmezas)

Main Article

Table 4

Native prion infectivity of concentrated and dialyzed as well as raw urine from 3 sCJDMM1 patients by bioassay in Tg40 mice*

Inoculum Incubation time, d Distribution
100× concentrated and dialyzed urine (sCJDMM1 patient 1) >736 0/10
100× concentrated and dialyzed (sCJDMM1 patient 2) >788 0/10
100× concentrated and dialyzed (sCJDMM1 patient 3) >788 0/8
100× concentrated and dialyzed (normal control 1) >719 0/5
100× concentrated and dialyzed (normal control 2) >756 0/5
100× concentrated and dialyzed (normal control 3) >752 0/5
Raw urine (sCJDMM1 patient 1) >857 0/33

*sCJD, sporadic Creutzfeldt-Jakob disease.

Main Article

1These authors contributed equally to this article.