Volume 18, Number 1—January 2012
Research
Assessing Prion Infectivity of Human Urine in Sporadic Creutzfeldt-Jakob Disease
Table 4
Native prion infectivity of concentrated and dialyzed as well as raw urine from 3 sCJDMM1 patients by bioassay in Tg40 mice*
Inoculum | Incubation time, d | Distribution |
---|---|---|
100× concentrated and dialyzed urine (sCJDMM1 patient 1) | >736 | 0/10 |
100× concentrated and dialyzed (sCJDMM1 patient 2) | >788 | 0/10 |
100× concentrated and dialyzed (sCJDMM1 patient 3) | >788 | 0/8 |
100× concentrated and dialyzed (normal control 1) | >719 | 0/5 |
100× concentrated and dialyzed (normal control 2) | >756 | 0/5 |
100× concentrated and dialyzed (normal control 3) | >752 | 0/5 |
Raw urine (sCJDMM1 patient 1) | >857 | 0/33 |
*sCJD, sporadic Creutzfeldt-Jakob disease.
1These authors contributed equally to this article.
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