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Volume 20, Number 1—January 2014
Research

Dynamic Modeling of Cost-effectiveness of Rotavirus Vaccination, Kazakhstan

Birgitte Freiesleben de BlasioComments to Author , Elmira Flem, Renat Latipov, Ajnagul Kuatbaeva, and Ivar Sønbø Kristiansen
Author affiliations: Norwegian Institute of Public Health, Oslo, Norway (B. Freiesleben de Blasio, E. Flem); University of Oslo, Norway (B. Freiesleben de Blasio, I.S. Kristiansen); Research Institute of Virology, Tashkent, Republic of Uzbekistan (R. Latipov); Scientific-Practical Centre of Epidemiologic Surveillance, Almaty, Republic of Kazakhstan (A. Kuatbaeva)

Main Article

Table 2

Description of scenarios for the economic evaluation of rotavirus vaccination, Kazakhstan

Scenario Vaccine parameters
 Children <5 y of age, calibration to 2009 sentinel data
Mean duration of protection, mo Coverage Efficacy against severe RVGE Efficacy against mild RVGE Deaths Hospital admissions Outpatient clinic visits* Homecare episodes*
Base case 12 0.9 0.80 0.58 68 4,007 Is-0.2Ih Im
Base case, low 12 0.9 0.74 0.51 63 3,740 0.6 0.5Im
Base case, high 12 0.9 0.86 0.64 74 4,274 1.4 1.5Im
Scenario A 12 0.89 0.80 0.58 68 4,007 Is-0.2Ih Im
Scenario A, low 12 0.89 0.74 0.51 63 3,740 0.6 0.5Im
Scenario A, high 12 0.89 0.86 0.64 74 4,274 1.4( 1.5Im
Scenario B 12 1.0 0.80 0.58 68 4,007 Is-0.2Ih Im
Scenario B, low 12 1.0 0.74 0.51 63 3,740 0.6 0.5Im
Scenario B, high 12 1.0 0.86 0.64 74 4,274 1.4 1.5Im
Scenario C 24 0.9 0.80 0.58 68 4,007 Is-0.2Ih Im
Scenario C, low 24 0.9 0.74 0.51 63 3,740 0.6 0.5Im
Scenario C, high 24 0.9 0.86 0.64 74 4,274 1.4 1.5Im

*RVGE, rotavirus gastroenteritis; Is, modeled incidence of severe RVGE; Ih, modeled incidence of hospital admissions; Im, modeled incidence of mild RVGE.
†The numbers of outpatient clinic and homecare visits were not calibrated.

Main Article

Page created: January 03, 2014
Page updated: January 03, 2014
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