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Volume 20, Number 1—January 2014

Research

Dynamic Modeling of Cost-effectiveness of Rotavirus Vaccination, Kazakhstan

Birgitte Freiesleben de BlasioComments to Author , Elmira Flem, Renat Latipov, Ajnagul Kuatbaeva, and Ivar Sønbø Kristiansen
Author affiliations: Norwegian Institute of Public Health, Oslo, Norway (B. Freiesleben de Blasio, E. Flem); University of Oslo, Norway (B. Freiesleben de Blasio, I.S. Kristiansen); Research Institute of Virology, Tashkent, Republic of Uzbekistan (R. Latipov); Scientific-Practical Centre of Epidemiologic Surveillance, Almaty, Republic of Kazakhstan (A. Kuatbaeva)

Main Article

Table 5

Estimated projected costs in US dollars and avoided health outcomes from rotavirus vaccination with 2-year protection, Kazakhstan, 2012–2031*

Outcome No vaccination Scenario C, 90% vaccine coverage, 2-y vaccination protection
Mean Low High
Avoided outcomes, undiscounted
Deaths 1,310 919 823 1,034
Hospital admissions 77,205 54,163 48,823 59,701
Out-patient visits 550,896 386,479 224,410 558,096
Home care episodes 2,675,456 1,544,202 747,494 2,390,646
Life-years gained
 NA
 57,183
 51,174
 64,306
Avoided costs, undiscounted, US $43 per vaccine dose
Vaccination NA 530.7 530.7 530.7
Prevented in-hospital care 25.7 19.7 17.8 21.8
Prevented outpatient care 16.3 12.5 7.3 18.1
Prevented homecare 8.5 5.4 2.6 8.4
Avoided indirect costs 179.4 130.7 95.2 169.2
Total net costs in US$
 229.9
 362.4
 407.8
 313.4
Incremental cost-effectiveness ratios, societal perspective
Discounted 3%
 NA
 16,775
 21,031
 12,952
Incremental cost-effectiveness ratios, health care perspective
Discounted 3%
 NA
 22:759
 25:898
 19:841
Threshold prices, 3% discounting
Medical break-even price† NA $2.95 $2.15 $3.79

*NA, not applicable.
†The price per vaccine dose at which the vaccinations costs are offset by cost saving generated from lower morbidity and mortality rates.

Main Article

Page created: January 03, 2014
Page updated: January 03, 2014
Page reviewed: January 03, 2014
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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