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Volume 20, Number 1—January 2014
Research

Molecular Barriers to Zoonotic Transmission of Prions

Marcelo A. Barria, Aru Balachandran, Masanori Morita, Tetsuyuki Kitamoto, Rona Barron, Jean Manson, Richard Knight, James W. Ironside, and Mark W. HeadComments to Author 
Author affiliations: The University of Edinburgh, Edinburgh, Scotland, UK (M.A. Barria, R. Knight, J.W. Ironside, M.W Head); Canadian Food Inspection Agency, Ottawa, Ontario, Canada (A. Balachandran); Japan Blood Products Organization, Kobe, Japan (M. Morita); Tohoku University Graduate School of Medicine, Sendai, Japan (T. Kitamoto); University of Edinburgh, Easter Bush, Scotland, UK (R. Barron, J. Manson)

Main Article

Figure 4

Relative conversion efficiency of human PrP (129M) by different animal prion disease samples. Brain homogenates from animal prion diseases were seeded at different volumes adjusted to give roughly equivalent amounts of seeding PrPres and amplified by using PrP 129M-containing human brain substrate. Human PrPres formation was detected by the 3F4 antibody (A) and seed and newly formed PrPres detected using the 6H4 antibody (B). PrP, protein prion; PrPres, protease-resistant PrP; M, molecular marke

Figure 4. . Relative conversion efficiency of human PrP (129M) by different animal prion disease samples. Brain homogenates from animal prion diseases were seeded at different volumes adjusted to give roughly equivalent amounts of seeding PrPres and amplified by using PrP 129M-containing human brain substrate. Human PrPres formation was detected by the 3F4 antibody (A) and seed and newly formed PrPres detected using the 6H4 antibody (B). PrP, protein prion; PrPres, protease-resistant PrP; M, molecular marker; BSE, bovine spongiform encephalopathy; CWD, chronic wasting disease; L-BSE, L-type BSE; H-BSE, H-type BSE; vCJD variant Creutzfeldt-Jakob disease; M, molecular marker.

Main Article

Page created: January 03, 2014
Page updated: January 03, 2014
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