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Volume 21, Number 4—April 2015
Research

Sequence Variability and Geographic Distribution of Lassa Virus, Sierra Leone

Tomasz A. Leski1Comments to Author , Michael G. Stockelman1, Lina M. Moses, Matthew Park, David A. Stenger, Rashid Ansumana, Daniel G. Bausch, and Baochuan Lin
Author affiliations: Naval Research Laboratory, Washington, DC, USA (T.A. Leski, M.G. Stockelman, D.A. Stenger, B. Lin); Tulane University, New Orleans, Louisiana, USA (L.M. Moses); Tulane School of Public Health and Tropical Medicine, New Orleans (L.M. Moses, D.G Bausch), Thomas Jefferson High School, Alexandria, Virginia, USA (M. Park); Mercy Hospital Research Laboratory, Bo, Sierra Leone (R. Ansumana); Liverpool School of Tropical Medicine, Liverpool, UK (R. Ansumana); Njala University, Bo (R. Ansumana)

Main Article

Table 3

Estimates of average evolutionary divergence of NP, GPC, and L gene fragments for Lassa virus strains, Sierra Leone*

Gene, grouping Difference†
Nucleotide Amino acid
NP
Overall 7.01 2.82
Clade A 5.03 2.06
Clade B 0.62 0.77
Clade C
 6.44
 2.42
GPC
Overall 8.92 4.06
Clade A 6.26 2.60
Clade B 0.68 0.49
Clade D
 7.49
 3.29
L
Overall 9.83 0.71
Clade A 6.59 0.58
Clade B 0.89 0.00
Clade D 0.88 0.00

*GPC, glycoprotein precursor; L, polymerase; NP, nucleoprotein.
†The numbers of nucleotide and amino acid differences per site from averaging over all sequence pairs or all sequence pairs within a clade multiplied by 100 are shown. All positions containing gaps and missing data were eliminated. Values for clade E defined for GPC and L sequences were not calculated because clade E contained only 1 sequence.

Main Article

1These authors contributed equally to this article.

Page created: March 17, 2015
Page updated: March 17, 2015
Page reviewed: March 17, 2015
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