Volume 22, Number 12—December 2016
Assessing the Epidemic Potential of RNA and DNA Viruses
|Reservoir host relatedness||Viruses derived from specific host taxa (e.g., other primate species might be of increased concern)|
|Virus relatedness||Particular virus taxa might be predisposed to infect, cause disease, and transmit among humans|
|Virus host range||Viruses with a broad or narrow host range might be of greatest concern|
|Evolvability||Higher substitution rates might make it easier for some viruses to adapt to human hosts|
|Host restriction factors||Host factors, many still to be identified, are a barrier to viral infection and help determine which viruses can and cannot emerge|
|Transmission route||Certain transmission routes might predispose viruses to emerge in humans|
|Virulence||Certain virus or host factors might determine whether a virus causes mild or severe disease in humans|
|Host−virus coevolution||Lack of a shared evolutionary history might be associated with higher virulence|
*Adapted from Morse et al. (3).
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Page updated: November 17, 2016
Page reviewed: November 17, 2016
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