Table 2

Invasive Group A Streptococcus Infection among Children, Rural Kenya

Anna C. Seale

, Mark R. Davies, Kirimi Anampiu, Susan C. Morpeth, Sammy Nyongesa, Salim Mwarumba, Pierre R. Smeesters, Androulla Efstratiou, Rosylene Karugutu, Neema Mturi, Thomas N. Williams, J. Anthony G. Scott, Samuel Kariuki, Gordon Dougan, and James A. Berkley

Author affiliations: KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya (A.C. Seale, K. Anampiu, S.C. Morpeth, S. Nyongesa, S. Mwarumba, N. Mturi, T.N. Williams, J.A.G. Scott, J.A. Berkley); University of Oxford, Oxford, UK (A.C. Seale, J.A. Berkley); University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia (M.R. Davies); University of Queensland, Brisbane, Queensland, Australia (M.R. Davies); The Wellcome Trust Sanger Institute, Cambridge, UK (M.R. Davies, S. Kariuki, G. Dougan); London School of Hygiene and Tropical Medicine, London, UK (S.C. Morpeth, J.A.G. Scott); Murdoch Children’s Research Institute, Melbourne, Victoria, Australia (P.R. Smeesters); University of Melbourne, Melbourne (P.R. Smeesters); Public Health England, London (A. Efstratiou); Imperial College, London (A. Efstratiou, T.N. Williams); The Kenya Medical Research Institute, Nairobi, Kenya (R. Karugutu, S. Kariuki)

Main Article

Common clinical syndromes of GAS disease among children admitted to Kilifi County Hospital, Kenya, 1998–2011

Clinical syndrome	Age
Clinical syndrome	0–6 d	7–28 d	29–59 d	60 d–1 y	>1–<5 y	5–12 y	Overall
All cases
No. (%)	33 (100)	61 (100)	17 (100)	63 (100)	125 (100)	70 (100)	369 (100)
Deaths, CFR	10 (30.3)	23 (37.7)	1 (6.3)	7 (11.1)	14 (11.2)	1 (1.4)	45 (12.2)
Skin and soft tissue infection
No. (%)	22 (66.7)	33 (54.1)	5 (29.4)	37 (58.7)	99 (79.2)	62 (88.6)	258 (69.9)
Deaths, CFR	6 (27.3)	4 (12.1)	0	1 (2.7)	6 (6.1)	1 (1.6)	17 (4.5)
Severe pneumonia†
No. (%)	7 (21.2)	17 (27.9)	8 (47.1)	28 (44.4)	21 (16.8)	3 (4.3)	86 (23.3)
Deaths, CFR	2 (28.6)	5 (29.4)	0	5 (17.9)	8 (38.1)	0	20 (23.3)
Primary bacteremia
No. (%)	8 (24.2)	17 (27.9)	3 (17.6)	9 (14.3)	13 (10.4)	3 (4.3)	53 (14.4)
Deaths, CFR	2 (25.0)	5 (29.4)	1 (33.3)	2 (22.2)	1 (7.7)	0	11 (20.8)

*CFR, case-fatality risk; GAS, group A Streptococcus.
†59 of the 86 severe pneumonia cases were complicated by sepsis.

Main Article

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