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Volume 22, Number 2—February 2016

Invasive Group A Streptococcus Infection among Children, Rural Kenya

Anna C. SealeComments to Author , Mark R. Davies, Kirimi Anampiu, Susan C. Morpeth, Sammy Nyongesa, Salim Mwarumba, Pierre R. Smeesters, Androulla Efstratiou, Rosylene Karugutu, Neema Mturi, Thomas N. Williams, J. Anthony G. Scott, Samuel Kariuki, Gordon Dougan, and James A. Berkley
Author affiliations: KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya (A.C. Seale, K. Anampiu, S.C. Morpeth, S. Nyongesa, S. Mwarumba, N. Mturi, T.N. Williams, J.A.G. Scott, J.A. Berkley); University of Oxford, Oxford, UK (A.C. Seale, J.A. Berkley); University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia (M.R. Davies); University of Queensland, Brisbane, Queensland, Australia (M.R. Davies); The Wellcome Trust Sanger Institute, Cambridge, UK (M.R. Davies, S. Kariuki, G. Dougan); London School of Hygiene and Tropical Medicine, London, UK (S.C. Morpeth, J.A.G. Scott); Murdoch Children’s Research Institute, Melbourne, Victoria, Australia (P.R. Smeesters); University of Melbourne, Melbourne (P.R. Smeesters); Public Health England, London (A. Efstratiou); Imperial College, London (A. Efstratiou, T.N. Williams); The Kenya Medical Research Institute, Nairobi, Kenya (R. Karugutu, S. Kariuki)

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Table 3

Estimated minimum incidence of definite and probable invasive GAS disease and deaths associated with invasive GAS disease in the catchment area of Kilifi County Hospital, Kenya, 1998–2011*

Incidence† Age group
Neonate, 0–27 d, n = 9,828‡ Infant, 28–59 d, n = 10,463‡ Infant, 2–11 mo, n = 92,070‡ Child 1–4 y, n = 453,857‡ Child 5–12 y, n = 730,512‡
Probable and definite invasive GAS disease incidence (95% CI) 631 (484–808) 105 (52–188) 43 (31–59) 19 (15–23) 6 (4–9)
Definite invasive GAS disease incidence (95% CI) 326 (223–459) 86 (39–163) 27 (18–40) 7 (5–10) 1 (0–1)
Death associated with all invasive GAS disease (95% CI) 163 (93–264) 10 (0–53) 5 (2–13) 2 (1–3) 0 (0–1)

*GAS, group A Streptococcus.
†Per 100,000 person-years.
‡Population denominator in person-years.

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Page created: January 14, 2016
Page updated: January 14, 2016
Page reviewed: January 14, 2016
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