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Volume 22, Number 5—May 2016
Research

Differences in Genotype, Clinical Features, and Inflammatory Potential of Borrelia burgdorferi sensu stricto Strains from Europe and the United States

Tjasa Cerar1, Franc Strle1, Dasa Stupica, Eva Ruzic-Sabljic, Gail McHugh, Allen C. Steere, and Klemen StrleComments to Author 
Author affiliations: University of Ljubljana, Ljubljana, Slovenia (T. Cerar, E. Ruzic-Sabljic); University Medical Center, Ljubljana (F. Strle, D. Stupica); Massachusetts General Hospital, Boston, Massachusetts, USA (G. McHugh, A.S. Steere, K. Strle)

Main Article

Table 3

Clinical characteristics of erythema migrans patients infected with Borrelia afzelii, B. garinii, or B. burgdorferi sensu stricto in Slovenia and B. burgdorferi sensu stricto in the United States*

B. afzelii, n = 200† B. garinii, n = 116† B. burgdorferi sensu stricto, n = 14
General
Age, y 50 (15–79) 54 (20–83) 50 (3–77) 49 (15–82) 0.6
Female sex 128 (64) 61 (53) 10 (71) 44 (49) 0.2
EM duration at study entry, d 9 (1–206) 5 (1–61) 7 (2–53) 4 (1–30) 0.02
EM diameter, cm
13 (5–86)
18 (5–72)
12 (5–38)
11 (5–56)
0.6
Symptoms at study entry
Symptoms/patient 0 (0–6) 0 (0–7) 0 (0–6) 4 (0–9) 0.005
Patients with symptoms 66 (33) 43 (37) 4 (29) 70 (78) <0.001
Fatigue 51 (26) 23 (20) 3 (21) 55 (61) 0.01
Arthralgia 30 (15) 21 (18) 3 (21) 42 (47) 0.1
Myalgia 28 (14) 22 (19) 3 (21) 28 (32) 0.7
Headache 27 (14) 21 (18) 4 (29) 45 (50) 0.2
Fever, chills 12 (6) 10 (9) 2 (14) 41 (46) 0.05
Neck stiffness 9 (5) 4 (3) 0 43 (48) 0.002
Malaise 21 (11) 21 (18) 2 (14) 47 (52) 0.01

*Values are median (range) or no. (%). EM, erythema migrans.
†Based on previously published data: B. burgdorferi sensu stricto (10); B. afzelii (5); B. garinii (20).
‡For comparison of B. burgdorferi sensu stricto from Slovenia versus the United States. Values in bold indicate statistical significance.

Main Article

1These authors contributed equally to this article.

Page created: April 13, 2016
Page updated: April 13, 2016
Page reviewed: April 13, 2016
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