Volume 23, Number 3—March 2017
Research
Zika Virus RNA Replication and Persistence in Brain and Placental Tissue
Table 4
Characteristics and laboratory findings of case-patients with adverse pregnancy outcome*
Case-patient no. | Maternal travel history or residence | Maternal symptom onset, gestation wk/trimester | Outcome | End of pregnancy, gestational age, wk/trimester | Results of Zika virus testing performed on FFPE tissues |
||
---|---|---|---|---|---|---|---|
RT-PCR | ISH† | ||||||
81 | Colombia | 1/first | SA | 6/first | Positive (placenta) | Positive (placenta) | |
47 | Honduras‡ | 5/first | SA | ≈8/first | Positive (placenta) | Positive (placenta) | |
57 | Puerto Rico‡ | 5/first | SA | 8/firstt | Positive (placenta) | Positive (placenta) | |
56 | Guatemala‡ | 6/first | SA | 11/first | Positive (placenta) | Positive (placenta) | |
18 | American Samoa | 7/first | SA | 14/second | Positive (placenta, fetal tissue) | Positive (placenta, fetal tissue) | |
78 | Colombia | 7/first | SA | 11/first | Positive (placenta) | Positive (placenta) | |
125 | Brazil | 8/first | SA | 11/first | Positive (placenta) | Positive (placenta) | |
256 | Brazil | 8/first | SA | 13/first | Positive (placenta) | Negative (placenta) | |
79 | Colombia | NA/first | SA | 9/first | Positive (placenta) | Positive (placenta) | |
80 | Mexico‡ | 6/first | SA | 12/first | Negative (placenta, cord) | ND | |
19 | Dominican Republic‡ | 1/first | SA | 10/first | Negative (placenta) | ND | |
45 | Honduras‡ | 13/first | ET | 19/second | Positive (placenta); negative umbilical cord, fetal brain, liver, lung) | Positive (placenta) | |
76 | Puerto Rico | 7/first | ET | 9/first | Positive (placenta) | Negative (placenta) | |
28 | Dominican Republic‡ | NA/first | ET | 16/second | Positive (placenta) | Negative (placenta) | |
97 | El Salvador | NA/first | IUFD§ | 34/third | Negative (placenta) | ND | |
92 | American Samoa | NA/second | IUFD | 24/second | Negative (placenta, umbilical cord, membrane) | ND | |
556 | Marshall Islands‡ | 31/third | IUFD | 36/third | Negative (placenta, umbilical cord, membrane) | ND |
*ET, elective termination; FFPE, formalin-fixed, paraffin-embedded; ISH, in situ hybridization; IUFD, intrauterine fetal demise; NA, not available; ND, not done; RT-PCR, reverse transcription PCR; SA, spontaneous abortion.
†ISH results include staining by both sense and antisense probes.
‡Travel history.
§With microcephaly.