Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 23, Number 4—April 2017

Significant Decrease in Pertactin-Deficient Bordetella pertussis Isolates, Japan

Yukihiro HiramatsuComments to Author , Yusuke Miyaji, Nao Otsuka, Yoshichika Arakawa, Keigo Shibayama, and Kazunari Kamachi
Author affiliations: National Institute of Infectious Diseases, Tokyo, Japan (Y. Hiramatsu, Y. Miyaji, N. Otsuka, K. Shibayama, K. Kamachi); St. Marianna University School of Medicine, Kawasaki, Japan (Y. Miyaji); Nagoya University Graduate School of Medicine, Nagoya, Japan (Y. Arakawa)

Main Article


Molecular mechanisms of loss of pertactin production in 59 pertactin-deficient Bordetella pertussis isolates, Japan, 2005–2016*

Reason for loss of pertactin
No. (%) MTs
ΔSS 0 43 (72.9) 11 (18.6)
1598–1599::IS481 0 2 (3.4) 1 (1.7)
245–246::IS481 1 (1.7) 0 0
Transcriptional downregulation
1 (1.7)
Total 2 (3.4) 45 (76.3) 12 (20.3)

*MT, types determined by using multilocus variable-number tandem-repeat analysis.
†For convenience, minor MTs (MT194, MT224–226, and MT314–316) are included in this category.

Main Article

Page created: March 16, 2017
Page updated: March 16, 2017
Page reviewed: March 16, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.