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Volume 23, Number 8—August 2017
Research

Characterization of Fitzroy River Virus and Serologic Evidence of Human and Animal Infection

Cheryl A. Johansen1Comments to Author , Simon H. Williams1, Lorna Melville, Jay Nicholson, Roy A. Hall, Helle Bielefeldt-Ohmann, Natalie A. Prow, Glenys R. Chidlow, Shani Wong, Rohini Sinha, David T. Williams, W. Ian Lipkin, and David W. Smith
Author affiliations: The University of Western Australia, Nedlands, Western Australia, Australia (C.A. Johansen, J. Nicholson, S. Wong, D.W. Smith); PathWest Laboratory Medicine Western Australia, Nedlands (C.A. Johansen, G.R. Chidlow, D.W. Smith); Columbia University, New York, New York, USA (S.H. Williams, R. Sinha, W.I. Lipkin); The Northern Territory Government, Darwin, Northern Territory, Australia (L.F. Melville); The University of Queensland, St. Lucia, Queensland, Australia (R.A. Hall, H. Bielefeldt-Ohmann, N.A. Prow); The University of Queensland, Gatton, Queensland, Australia (H. Bielefeldt-Ohmann); CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia (D.T. Williams)

Main Article

Figure 3

Photomicrographs of Fitzroy River virus (FRV)–induced meningoencephalitis in weanling mice inoculated with 1,000 infectious units of FRV. Panels show multifocal mild to severe perivascular and neuropil infiltration of lymphocytes and monocytes (blue arrows in A–C); meningitis in a sulcus (black arrow in A); glial cell activation with notable astrocytosis, neuron degeneration, and neuronophagia (arrowhead in B); occasional hemorrhage (blue arrow in D); mild periventricular spongiosis (blues arrow

Figure 3. Photomicrographs of Fitzroy River virus (FRV)–induced meningoencephalitis in weanling mice inoculated with 1,000 infectious units of FRV. Panels show multifocal mild to severe perivascular and neuropil infiltration of lymphocytes and monocytes (blue arrows in A–C); meningitis in a sulcus (black arrow in A); glial cell activation with notable astrocytosis, neuron degeneration, and neuronophagia (arrowhead in B); occasional hemorrhage (blue arrow in D); mild periventricular spongiosis (blue arrows in C); and meningitis (black arrow in C). Hematoxylin and eosin staining. Original magnifications: A) ×40, B) ×400, C) ×100, D) ×400.

Main Article

1These authors contributed equally to this article.

Page created: July 17, 2017
Page updated: July 17, 2017
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