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Volume 23, Number 9—September 2017

Research

Protective Effect of Val129-PrP against Bovine Spongiform Encephalopathy but not Variant Creutzfeldt-Jakob Disease

Natalia Fernández-Borges1, Juan Carlos Espinosa1, Alba Marín-Moreno, Patricia Aguilar-Calvo, Emmanuel A. Asante, Tetsuyuki Kitamoto, Shirou Mohri, Olivier Andréoletti, and Juan María TorresComments to Author 
Author affiliations: Centro de Investigación en Sanidad Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (CISA-INIA); Valdeolmos, Madrid, Spain (N. Fernández-Borges, J.C. Espinosa, A. Marín-Moreno, P. Aguilar-Calvo, J.M. Torres); MRC Prion Unit, Department of Neurodegenerative Disease, University College London, Institute of Neurology, London, UK (E.A. Asante); Tohoku University Graduate School of Medicine, Sendai, Japan (T. Kitamoto, S. Mohri); UMR INRA ENVT 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France (O. Andréoletti)

Main Article

Figure 2

Protease-resistant prion protein distribution pattern in brains of prion protein humanized transgenic mice inoculated with variant Creutzfeldt-Jakob disease (vCJD) on second passage. A, B) TgMet129 mice inoculated with vCJD. C) TgMet/Val129 mice inoculated with vCJD. D, E) TgVal129 mice inoculated with vCJD propagated in TgMet129 mice. Original magnification ×20 for all panels.

Figure 2. Protease-resistant prion protein distribution pattern in brains of prion protein humanized transgenic mice inoculated with variant Creutzfeldt-Jakob disease (vCJD) on second passage. A, B) TgMet129 mice inoculated with vCJD. C) TgMet/Val129 mice inoculated with vCJD. D, E) TgVal129 mice inoculated with vCJD propagated in TgMet129 mice. Original magnification ×20 for all panels.

Main Article

1These authors contributed equally to this article.

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