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Volume 23, Number 9—September 2017

Research

Protective Effect of Val129-PrP against Bovine Spongiform Encephalopathy but not Variant Creutzfeldt-Jakob Disease

Natalia Fernández-Borges1, Juan Carlos Espinosa1, Alba Marín-Moreno, Patricia Aguilar-Calvo, Emmanuel A. Asante, Tetsuyuki Kitamoto, Shirou Mohri, Olivier Andréoletti, and Juan María TorresComments to Author 
Author affiliations: Centro de Investigación en Sanidad Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (CISA-INIA); Valdeolmos, Madrid, Spain (N. Fernández-Borges, J.C. Espinosa, A. Marín-Moreno, P. Aguilar-Calvo, J.M. Torres); MRC Prion Unit, Department of Neurodegenerative Disease, University College London, Institute of Neurology, London, UK (E.A. Asante); Tohoku University Graduate School of Medicine, Sendai, Japan (T. Kitamoto, S. Mohri); UMR INRA ENVT 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France (O. Andréoletti)

Main Article

Table 1

Description of prion isolates used in analysis of bovine spongiform encephalopathy and Creutzfeldt-Jakob disease*

Isolate Sample codification Description (reference) Supplier†
Hu-sCJD MM1 BC 1011 sCJD PrP-Met129 type 1 human natural case BHUFA
Hu-sCJD VV2 BC 1452 sCJD PrP-Val129 type 2 human natural case BHUFA
Hu-TSE negative TSE free human brain NIBSC
Ca-BSE0 Fr (139) BSE naturally infected cow (31,32) INRA
Ca-BSE2 UK (PG1199/00) BSE naturally infected cow (33,34) VLA
Ca-BSE0/TgPo Ca-BSE0/Tg001 BSE transmitted experimentally to porcine transgenic mice (32) CISA
Ca-BSE0/Sh(ARQ) Fr (ARQ0) Pool of brains from terminally ill ARQ/ARQ sheep inoculated with Ca-BSE (31,32) INRA
Ca-BSE/Go gBSE-P12 Pool of brains from 3 terminally ill wild type goats inoculated with a mixture of 4 cattle-BSE field cases (3537) Roslin
Go-BSE Fr (CH636) Goat BSE case (38) AFSSA
Hu-vCJD1 UK (NHBY/0014) vCJD PrP-Met129 human infected case (39) NIBSC
Hu-vCJD2 BC 1458 vCJD PrP-Met129 human infected case BHUFA

*BSE, bovine spongiform encephalopathy; Ca, cattle; CJD, Creutzfeldt-Jakob disease; Go, goat; Hu, human; Met129, methionine; PrP, prion protein; sCJD, sporadic CJD; TSE, transmissible spongiform encephalopathy; Val129, valine; vCJD, variant CJD.
†AFSSA, Agence Française de Sécurité Sanitaire des Aliments National TSE Reference Laboratory, Lyon, France; BHUFA, Biobanco Hospital Universitario Fundación Alcorcón, Madrid, Spain; CISA, Centro de Investigación en Sanidad Animal, Madrid, Spain; INRA, French National Institute for Agricultural Research, Nouzilly, France; NIBSC, National Institute for Biologic Standards and Control Creutzfeld-Jakob Disease Resource Centre, South Mimms, Potters Bar, United Kingdom; Roslin, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, United Kingdom; VLA, Veterinary Laboratory Agency, New Haw. Addlestone, Surrey, United Kingdom.

Main Article

1These authors contributed equally to this article.

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